ID   A0A9L0JKX4_EQUAS        Unreviewed;       410 AA.
AC   A0A9L0JKX4;
DT   13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 1.
DT   02-SEP-2026, entry version 15.
DE   SubName: Full=TNF receptor superfamily member 1A {ECO:0000313|Ensembl:ENSEASP00005050612.1};
GN   Name=TNFRSF1A {ECO:0000313|Ensembl:ENSEASP00005050612.1};
OS   Equus asinus (Donkey) (Equus africanus asinus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9793 {ECO:0000313|Ensembl:ENSEASP00005050612.1, ECO:0000313|Proteomes:UP000694387};
RN   [1] {ECO:0000313|Ensembl:ENSEASP00005050612.1, ECO:0000313|Proteomes:UP000694387}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=33293529;
RA   Wang, C., Li, H., Guo, Y., Huang, J., Sun, Y., Min, J., Wang, J., Fang, X.,
RA   Zhao, Z., Wang, S., Zhang, Y., Liu, Q., Jiang, Q., Wang, X., Guo, Y., Yang,
RA   C., Wang, Y., Tian, F., Zhuang, G., Fan, Y., Gao, Q., Li, Y., Ju, Z., Li,
RA   J., Li, R., Hou, M., Yang, G., Liu, G., Liu, W., Guo, J., Pan, S., Fan, G.,
RA   Zhang, W., Zhang, R., Yu, J., Zhang, X., Yin, Q., Ji, C., Jin, Y., Yue, G.,
RA   Liu, M., Xu, J., Liu, S., Jordana, J., Noce, A., Amills, M., Wu, D.D., Li,
RA   S., Zhou, X. and Zhong, J.;
RT   "Donkey genomes provide new insights into domestication and selection for
RT   coat color.";
RL   Nat. Commun. 11:6014-6014(2020).
RN   [2] {ECO:0000313|Ensembl:ENSEASP00005050612.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2026) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR   AlphaFoldDB; A0A9L0JKX4; -.
DR   Ensembl; ENSEAST00005054546.1; ENSEASP00005050612.1; ENSEASG00005016176.2.
DR   GeneTree; ENSGT00940000159540; -.
DR   Proteomes; UP000694387; Chromosome 22.
DR   GO; GO:0045121; C:membrane raft; IEA:TreeGrafter.
DR   GO; GO:0043235; C:signaling receptor complex; IEA:TreeGrafter.
DR   GO; GO:0043120; F:tumor necrosis factor binding; IEA:TreeGrafter.
DR   GO; GO:0005031; F:tumor necrosis factor receptor activity; IEA:TreeGrafter.
DR   GO; GO:0006954; P:inflammatory response; IEA:TreeGrafter.
DR   CDD; cd08313; Death_TNFR1; 1.
DR   FunFam; 1.10.533.10:FF:000044; Tumor necrosis factor receptor superfamily member 1A; 1.
DR   FunFam; 2.10.50.10:FF:000025; Tumor necrosis factor receptor superfamily member 1A; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_dom.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   InterPro; IPR052493; TNFRSF1A.
DR   InterPro; IPR033994; TNFRSF1A_death.
DR   PANTHER; PTHR46861; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1A; 1.
DR   PANTHER; PTHR46861:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1A; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF00020; TNFR_c6; 2.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00208; TNFR; 3.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF57586; TNF receptor-like; 2.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS00652; TNFR_NGFR_1; 1.
DR   PROSITE; PS50050; TNFR_NGFR_2; 2.
PE   4: Predicted;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694387};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..410
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5040154529"
FT   TRANSMEM        172..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          43..82
FT                   /note="TNFR-Cys"
FT                   /evidence="ECO:0000259|PROSITE:PS50050"
FT   REPEAT          43..82
FT                   /note="TNFR-Cys"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT   DOMAIN          83..126
FT                   /note="TNFR-Cys"
FT                   /evidence="ECO:0000259|PROSITE:PS50050"
FT   REPEAT          83..126
FT                   /note="TNFR-Cys"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT   DOMAIN          311..396
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
SQ   SEQUENCE   410 AA;  45472 MW;  79D31B143FD17D57 CRC64;
     MGLPAVPGLL PPLALLALLV EIYPSGVTGL VPPLRDREKR DSLCPQGKYS HPQNNSICCT
     KCHKEMNQVE ISSCTVDRDT VCGCRKNQYR KYWSETSETR FQCLDCSLCI NGTVHLPCQE
     RQNTVCTCHT GFFLKENECM SCVKCKKDAE CTKLCPSPTQ SVTGRQDPGA TVLLPLVIFL
     GLCLLSLLSI GFLCRYRRWK PKLRSIVCGK STPVKEGEPE PLAPTPSFSP TAALSVIPGY
     SPVSSSTFTP IPNFTPSDWR NFSAASPPRE MAPPYQEAGP ILTAVPPSSP LSTPVQKWED
     SAHTQRPDTD PATLYAVVDG VPPSRWKEFV RRLGLSEHEI ERLELQNGRC LREAHYSMLA
     AWRRRTPRRE ATLELLGSVL RDMDLLGCLE DIQEKLCAPA SHSPAPRLPR
//