id: A0A8C5FPT8
gene_symbol: tbc1d14
taxon:
  id: NCBITaxon:8049
  label: Gadus morhua
status: COMPLETE
description: >-
  The sequence relationship to vertebrate TBC1D14 and a verified experimental localization annotation
  on human TBC1D14 support inferred autophagosome association. This need not be the protein's predominant
  compartment.
source_documents:
  - genes/GADMO/A0A8C5FPT8/A0A8C5FPT8-uniprot.txt
  - genes/GADMO/A0A8C5FPT8/A0A8C5FPT8-goa.tsv
  - publications/PMID_22613832.md
  - genes/GADMO/A0A8C5FPT8/A0A8C5FPT8-prediction-evidence/protnlm.json
  - genes/GADMO/A0A8C5FPT8/A0A8C5FPT8-prediction-evidence/A6H7I8-uniprot.txt
  - genes/GADMO/A0A8C5FPT8/A0A8C5FPT8-prediction-evidence/Q9P2M4-autophagosome-goa.json
  - genes/GADMO/A0A8C5FPT8/A0A8C5FPT8-hypotheses/prediction-autophagosome/openscientist.md
predictions:
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0005776
      label: autophagosome
    predicted_term_type: GO_CC
    review:
      assessment: COR
      confidence_score: 2
      summary: >-
        The target has TBC1D14-like architecture and a strong phmmer match to reviewed bovine TBC1D14
        A6H7I8 (reported score 791.8 in the raw evidence record). QuickGO records human TBC1D14 Q9P2M4
        at autophagosomes with an IDA assigned by BHF-UCL from PMID:22613832, alongside a curated IBA;
        these are verified annotation records rather than an AI verdict. The paper emphasizes recycling
        endosomes and Golgi redistribution, so the localization should not be read as exclusive or constitutive
        autophagosome residence. The conserved sequence relationship and experimentally grounded curator
        annotation support broad localization transfer to cod despite the differing PANTHER subfamily
        label. The target itself lacks this term in cached GOA/UniProt, making this a supported additional
        annotation, not a target experiment or an existing target match.
      supported_by:
        - reference_id: file:GADMO/A0A8C5FPT8/A0A8C5FPT8-uniprot.txt
          supporting_text: >-
            ID   A0A8C5FPT8_GADMO        Unreviewed;       709 AA. ... DR   InterPro; IPR000195; Rab-GAP-TBC_dom.
            ... DR   PANTHER; PTHR47219:SF15; TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1; 1. ... FT   DOMAIN          388..596
            ... FT                   /note="Rab-GAP TBC"
        - reference_id: PMID:22613832
          supporting_text: >-
            TBC1D14 binds activated Rab11 but is not a GAP for Rab11
        - reference_id: file:GADMO/A0A8C5FPT8/A0A8C5FPT8-prediction-evidence/protnlm.json
          supporting_text: >-
            "key": "phmmer_accession", "value": "A6H7I8"
        - reference_id: file:GADMO/A0A8C5FPT8/A0A8C5FPT8-prediction-evidence/A6H7I8-uniprot.txt
          supporting_text: >-
            ID   TBC14_BOVIN             Reviewed;         692 AA. ... GN   Name=TBC1D14; ... DR   GO;
            GO:0005776; C:autophagosome; IBA:GO_Central. ... DR   GO; GO:0055037; C:recycling endosome;
            IBA:GO_Central. ... DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central. ...
            DR   GO; GO:2000785; P:regulation of autophagosome assembly; IBA:GO_Central. ... DR   PANTHER;
            PTHR47219:SF21; TBC1 DOMAIN FAMILY MEMBER 14; 1. ... FT   DOMAIN          400..610 ... FT                   /note="Rab-GAP
            TBC"
        - reference_id:
            file:GADMO/A0A8C5FPT8/A0A8C5FPT8-prediction-evidence/Q9P2M4-autophagosome-goa.json
          supporting_text: >-
            "geneProductId": "UniProtKB:Q9P2M4" ... "goId": "GO:0005776" ... "goEvidence": "IDA", "goAspect":
            "cellular_component", "evidenceCode": "ECO:0000314", "reference": "PMID:22613832"
        - reference_id: file:GADMO/A0A8C5FPT8/A0A8C5FPT8-hypotheses/prediction-autophagosome/openscientist.md
          supporting_text: Autophagosome is a **secondary, condition-dependent** localization
references:
  - id: file:GADMO/A0A8C5FPT8/A0A8C5FPT8-uniprot.txt
    title: A0A8C5FPT8-uniprot.txt
  - id: PMID:22613832
    title: TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling
      endosomes.
  - id: file:GADMO/A0A8C5FPT8/A0A8C5FPT8-prediction-evidence/protnlm.json
    title: protnlm.json
  - id: file:GADMO/A0A8C5FPT8/A0A8C5FPT8-prediction-evidence/A6H7I8-uniprot.txt
    title: A6H7I8-uniprot.txt
  - id: file:GADMO/A0A8C5FPT8/A0A8C5FPT8-prediction-evidence/Q9P2M4-autophagosome-goa.json
    title: Q9P2M4-autophagosome-goa.json
  - id: file:GADMO/A0A8C5FPT8/A0A8C5FPT8-hypotheses/prediction-autophagosome/openscientist.md
    title: Focused OpenScientist report on A0A8C5FPT8 autophagosome prediction
    reference_review:
      relevance: HIGH
      review_notes: >-
        Substantive computational synthesis directly addressing the autophagosome prediction. The report's
        key sequence and annotation claims are independently corroborated by the cached UniProt TBC-domain
        record, the phmmer hit to bovine TBC1D14, and the QuickGO record for experimentally supported
        human TBC1D14 autophagosome localization. The report supports a conserved secondary localization
        hypothesis; it does not establish that autophagosome residence is constitutive or predominant
        for the cod protein.