| Kinase/Protein | Organism/Species | Pathways Involved | Biological Processes | Experimental/Bioinformatic Evidence | Key References (with year, URL if available) |
|---|---|---|---|---|---|
| **S0EDH7 / FFUJ_06423** (protein kinase domain-containing protein; kinase-like superfamily domain IPR011009) | *Gibberella fujikuroi* / *Fusarium fujikuroi* strain CBS 195.34 / IMI 58289 / NRRL A-6831 | Unknown; only general inference to protein-kinase-mediated signaling is currently justified | Unknown; no direct evidence for catalytic activity, substrates, localization, or pathway membership was identified in the retrieved literature | No direct functional study for S0EDH7/FFUJ_06423 was found in the available literature/tool results. Annotation supports only that it is a kinase-domain-containing protein; specific function remains uncharacterized and should not be inferred beyond domain-level prediction | UniProt-derived target description provided by user; no direct paper match in retrieved literature (pqac-00000013, pqac-00000014) |
| **FfTOR** (target of rapamycin kinase) | *Fusarium fujikuroi* | TOR signaling; FKBP12–TOR pathway; crosstalk with AreA/glutamine synthetase-mediated nitrogen regulation | Essential growth control; regulation of gibberellin (GA) and bikaverin biosynthesis; translation control; ribosome biogenesis; carbon metabolism; autophagy | Direct experimental evidence: rapamycin inhibition caused drastic growth defects; **tor** knockout was lethal; gene expression of AreA-dependent targets changed according to nitrogen source/concentration; microarray showed TOR-dependent regulation of translation/ribosome/autophagy genes (pqac-00000005, pqac-00000013) | Teichert et al. 2006, discussed in Song et al. 2024, *Mol Plant Pathol*; https://doi.org/10.1111/mpp.70024 (pqac-00000005, pqac-00000006) |
| **TOR pathway components** (TOR, LST8, RAPTOR/KOG1, putative TORC2 parts and upstream regulators) | Phytopathogenic fungi broadly, including *Fusarium* spp. | TORC1/TORC2; upstream FKBP12, VPS34-PLD1, AMPK/SNF1, PDK/PTEN/PKB, Rag/GTR nutrient signaling | Nutrient sensing, growth control, autophagy, translation, virulence-associated signaling | Comparative genomics/BLAST-based annotation showed conservation of TOR kinase domain architecture and many TOR pathway components across phytopathogenic fungi; pathway incompleteness in some species suggests lineage-specific rewiring rather than absence of TOR signaling (pqac-00000006, pqac-00000008) | Song et al. 2024, *Mol Plant Pathol*; https://doi.org/10.1111/mpp.70024 (pqac-00000006, pqac-00000008) |
| **GTR1 and TSC2** (TOR upstream regulators) | *Verticillium dahliae* | TOR signaling; MAPK–TOR crosstalk; autophagy-linked nutrient/host sensing | Chemotropism toward nutrients and plant signals; hyphal morphology; virulence | Gene knockout studies showed abnormal morphology/hyphal growth and increased chemotropic responses; pathogenicity defects were linked to TOR-regulated autophagy dysfunction; highlighted as evidence for TOR pathway control of invasive growth behavior in plant pathogens (pqac-00000005) | Vangalis et al. 2023, summarized in Song et al. 2024; https://doi.org/10.1111/mpp.70024 (pqac-00000005) |
| **VdTOR** | *Verticillium dahliae* | TOR signaling | Mycelial growth, conidiation, pathogenicity, expression of cell wall-degrading enzyme genes | Rapamycin retarded mycelial growth and conidial development; RNA-seq under TOR inhibition identified DEGs involved in growth and invasion, including CWDEs, supporting a conserved TOR-regulated virulence program (pqac-00000005) | Li et al. 2019, summarized in Song et al. 2024; https://doi.org/10.1111/mpp.70024 (pqac-00000005) |
| **SsTOR** | *Sclerotinia sclerotiorum* | TOR signaling; cell wall integrity (via SsSMK3 phosphorylation); autophagy (SsATG1/SsATG13) | Hyphal growth; sclerotia formation; compound appressoria formation; abiotic stress response; pathogenicity | Silencing of **SsTOR** retarded growth and infection-related development; pathway linked experimentally to CWI and autophagy, illustrating how fungal TOR kinases act as master developmental regulators relevant to plant disease control (pqac-00000005) | Jiao et al. 2023, summarized in Song et al. 2024; https://doi.org/10.1111/mpp.70024 (pqac-00000005) |
| **Rheb–TORC1 axis** | *Ustilago maydis* | TORC1 signaling downstream of Rheb and TSC complex | Ribosome synthesis, autophagy repression, infection capacity | Null **tor1** mutants were not recovered, indicating essentiality; gain-of-function Rheb mutants that maintain high TORC1 activity showed impaired infection, illustrating conserved but context-dependent TOR control of virulence (pqac-00000005) | de la Torre & Pérez-Martín 2022; Yang et al. 2021, summarized in Song et al. 2024; https://doi.org/10.1111/mpp.70024 (pqac-00000005) |
| **AMPK/SNF1–TOR linkage** | Broadly conserved in phytopathogenic fungi; explicitly discussed for *Phytophthora infestans* and comparative fungal datasets | AMPK/SNF1–TSC2–TOR nutrient/energy signaling | ROS stress response, development, pathogenicity, metabolic adaptation | Review/comparative evidence identifies AMPK homologues across surveyed phytopathogens and describes experimental targeting of AMPK kinase complex in *P. infestans*, supporting conserved TOR coupling to energy sensing in invasive microbes (pqac-00000008, pqac-00000005) | Song et al. 2024, *Mol Plant Pathol*; https://doi.org/10.1111/mpp.70024 (pqac-00000005, pqac-00000008) |
| **PkhA/PkhB** (AGC-kinase pathway components named in comparative biosynthetic survey) | Pathogenic *Fusarium* spp. | Not assigned to S0EDH7; likely signaling kinases represented in comparative domain analyses | Not resolved in the retrieved text; included as examples that kinase-encoding loci exist in comparative *Fusarium* datasets | Bioinformatic/domain comparison in secondary metabolite-focused comparative genomics identified kinase-named homolog sets (e.g., PkhA/PkhB), but without direct functional assignment to S0EDH7 or *F. fujikuroi* TOR biology in the retrieved evidence (pqac-00000000, pqac-00000004) | Lin et al. 2023, *J Fungi*; https://doi.org/10.3390/jof9080850 (pqac-00000000, pqac-00000004) |
| **General kinase signaling modules in *F. fujikuroi*** (MAPK, Ras, G-protein, cAMP pathway genes) | *Fusarium fujikuroi* | MAPK signaling, Ras small GTPase pathways, G-protein signaling, cAMP signaling | Host-pathogen interaction, metabolic regulation, development, virulence | Review-level synthesis indicates these signaling genes are involved in *F. fujikuroi* biology, but the retrieved evidence did not map S0EDH7 specifically to any one module; useful only as contextual inference for uncharacterized kinase-domain proteins (pqac-00000013) | Cen et al. 2020, *Front Bioeng Biotechnol*; https://doi.org/10.3389/fbioe.2020.00232 (pqac-00000013) |


*Table: This table summarizes the available evidence for kinase domain-containing proteins in Fusarium fujikuroi and related phytopathogenic fungi, emphasizing the better-characterized TOR pathway. It is useful for distinguishing what is directly known for the target S0EDH7 from broader cross-species inferences that can inform cautious functional annotation.*