id: A0A9L0RRL6
gene_symbol: ALDH7A1
taxon:
  id: NCBITaxon:9796
  label: Equus caballus
status: COMPLETE
description: The exact glyceraldehyde-3-phosphate substrate prediction cannot be established from ALDH7A1
  family membership or from experiments on other aldehydes. The selected horse model also has an internal
  deletion of unresolved functional consequence.
source_documents:
- publications/PMID_20207735.md
- publications/PMID_16491085.md
- genes/HORSE/ALDH7A1/ALDH7A1-bioinformatics/RESULTS.md
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  predicted_term:
    id: GO:0043878
    label: glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
  predicted_term_type: GO_MF
  review:
    assessment: UNC
    confidence_score: 1
    summary: Human ALDH7A1 is an alpha-aminoadipic-semialdehyde dehydrogenase with experimentally demonstrated
      activity on several additional aldehydes. Those results establish ALDH chemistry but do not establish
      glyceraldehyde-3-phosphate oxidation. The selected horse sequence retains catalytic residues but
      has an internal 18-residue deletion, further limiting an exact substrate transfer. No target GOA
      overlap or direct glyceraldehyde-3-phosphate assay was found in the inspected evidence. The different
      canonical substrate alone does not prove the predicted reaction is impossible for a broad-specificity
      ALDH, so the prediction remains uncertain rather than receiving a confident paralog-error label.
    supported_by:
    - reference_id: PMID:20207735
      supporting_text: 'including the osmolyte precursor, betaine aldehyde, lipid peroxidation-derived

        aldehydes, and the intermediate lysine degradation product, alpha-aminoadipic

        semialdehyde.'
    - reference_id: file:HORSE/ALDH7A1/ALDH7A1-bioinformatics/RESULTS.md
      supporting_text: Global alignment of cached UniProt sequences gives **498/521 identical paired residues
        (95.6%)**.
references:
- id: PMID:20207735
  title: Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic
    stress.
- id: file:HORSE/ALDH7A1/ALDH7A1-bioinformatics/RESULTS.md
  title: ALDH7A1 human–horse sequence comparison