id: A0A5F5PZM5
gene_symbol: CACNB3
taxon:
  id: NCBITaxon:9796
  label: Equus caballus
status: COMPLETE
description: Assessment of 1 ProtNLM GO predictions for the selected horse CACNB3 protein, using mammalian
  experimental findings and an explicit comparison of the horse sequence.
source_documents:
- genes/human/CACNB3/CACNB3-uniprot.txt
- genes/HORSE/CACNB3/CACNB3-bioinformatics/RESULTS.md
- projects/PROTNLM_EVALUATION/mammal-benchmark/horse40-predictions.csv
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  predicted_term:
    id: GO:0034765
    label: regulation of monoatomic ion transmembrane transport
  predicted_term_type: GO_BP
  review:
    assessment: COR
    confidence_score: 2
    summary: Human CACNB3 coexpression experiments demonstrate modulation of voltage-dependent calcium
      channels (PMID:8119293). The horse protein spans the complete human reference with 97.11% identity,
      supporting conservation of the regulatory beta-subunit architecture. Regulation of ion transmembrane
      transport is therefore supported without assigning a pore-forming function to the beta subunit.
      The exact process term is absent from target GOA, which contains calcium-transport and channel-complex
      annotations; this is target annotation novelty, not evidence about model training. Training-set
      membership is unknown.
    supported_by:
    - reference_id: file:human/CACNB3/CACNB3-uniprot.txt
      supporting_text: 'CC   -!- FUNCTION: Regulatory subunit of the voltage-gated calcium channel that

        CC       gives rise to L-type calcium currents (PubMed:8119293). Increases

        CC       CACNA1B peak calcium current and shifts the voltage dependencies of

        CC       channel activation and inactivation (By similarity). Increases CACNA1C

        CC       peak calcium current and shifts the voltage dependencies of channel

        CC       activation and inactivation (By similarity).

        CC       {ECO:0000250|UniProtKB:P54287, ECO:0000250|UniProtKB:Q9MZL3,

        CC       ECO:0000269|PubMed:8119293}.'
    - reference_id: file:HORSE/CACNB3/CACNB3-bioinformatics/RESULTS.md
      supporting_text: The horse sequence A0A5F5PZM5 (517 residues) aligns to human P54284 (484 residues)
        with 97.11% identity across 484 paired residues. Paired coverage is 100.0% of the human sequence
        and 93.62% of the horse sequence.
    - reference_id: PMID:8119293
      supporting_text: 'The cloned H beta 3

        subunit was further expressed in Xenopus oocytes to demonstrate its ability to

        modulate VDCC activity.'
references:
- id: file:human/CACNB3/CACNB3-uniprot.txt
  title: UniProt record for human CACNB3
  findings: []
- id: file:HORSE/CACNB3/CACNB3-bioinformatics/RESULTS.md
  title: "CACNB3: horse\u2013human sequence comparison"
  findings: []
- id: PMID:8119293
  title: Cloning, chromosomal location and functional expression of the human voltage-dependent calcium-channel
    beta 3 subunit.
  findings: []