ProtNLM2 External predictions
View prediction review YAML · CTDSP2-protnlm-predictions-review.yaml · Review status: COMPLETE
Kinase activity is unsupported for the selected short CTDSP2 protein model. Its sequence lacks the canonical human CTDSP2 catalytic region, so neither a normal phosphatase function nor a definitive alternative catalytic verdict can be transferred from the gene symbol.
Source documents: genes/HORSE/CTDSP2/CTDSP2-uniprot.txt · genes/HORSE/CTDSP2/CTDSP2-bioinformatics/RESULTS.md · genes/HORSE/CTDSP2/CTDSP2-bioinformatics/alignment.txt · genes/human/CTDSP2/CTDSP2-uniprot.txt
Review score: 2 = concordant with evidence; 1 = uncertain; 0 = discordant with evidence. This is an assessment score, not a model probability.
UNC — Uncertain Review score: 1/2
Prediction method: ProtNLM2 · Version: UniProt API snapshot 2026-09-08
Review rationale: No kinase mechanism is supported for F7A4N8. The selected 174-residue sequence matches the N-terminal portion of human CTDSP2 but diverges before the FCP1 catalytic domain and lacks its conserved catalytic aspartates. A phosphatase-versus-kinase contradiction based only on the CTDSP2 gene name would therefore overstate the evidence for this exact input. The current sequence and domain record argue against an ordinary protein kinase but do not provide a structural or biochemical assessment sufficient to exclude every kinase activity. Resolve the protein model and inspect its structure before a definitive catalytic adjudication; no target GOA overlap exists.
Supporting Evidence:
- file:HORSE/CTDSP2/CTDSP2-uniprot.txt: "ID F7A4N8_HORSE Unreviewed; 174 AA."
- file:human/CTDSP2/CTDSP2-uniprot.txt: "FT ACT_SITE 107"
- file:HORSE/CTDSP2/CTDSP2-bioinformatics/RESULTS.md: "Global alignment of cached UniProt sequences gives **97/170 identical paired residues (57.1%)**."