# CTDSP2 (horse) re-review: gene model and phylogenetic placement

Generated by `compare_sequences_rereview.py` from UniProt sequences (rereview_sequences.fasta) and the Ensembl gene model for ENSECAG00000018788 (rereview_ensembl_gene.json). Values are computed, not hand-entered.

## Ensembl transcripts of the horse CTDSP2 gene

| Transcript | Ensembl canonical | Protein length | Exons (genomic, transcript order) |
|---|---|---|---|
| ENSECAT00000020049 | False | 174 | 76314118-76314097 (22 bp); 76313944-76313894 (51 bp); 76313858-76313769 (90 bp); 76300657-76300509 (149 bp); 76298730-76298692 (39 bp); 76298535-76298161 (375 bp); 76297551-76297495 (57 bp); 76295282-76295190 (93 bp); 76295050-76294865 (186 bp); 76294666-76292229 (2438 bp) |
| ENSECAT00000138494 | False | 252 | 76314106-76313769 (338 bp); 76300657-76300509 (149 bp); 76298730-76298692 (39 bp); 76298262-76298161 (102 bp); 76295282-76295190 (93 bp); 76295050-76294865 (186 bp); 76294666-76291030 (3637 bp) |
| ENSECAT00000107019 | True | 312 | 76314416-76313912 (505 bp); 76313805-76313769 (37 bp); 76300657-76300509 (149 bp); 76298262-76298161 (102 bp); 76297551-76297495 (57 bp); 76295282-76295190 (93 bp); 76295050-76294865 (186 bp); 76294666-76291041 (3626 bp) |

## Horse CTDSP2-gene products compared with human CTDSP2 (O14595)

Human DxDx(T/V) motif(s): [(107, 'DLDET')]

| Product | Length | Shared prefix with human before divergence | Global identity vs human (identical/paired) | DxDx(T/V) motifs |
|---|---|---|---|---|
| horse_CTDSP2gene_F7A4N8 | 174 | 84 | 109/164 | none |
| horse_CTDSP2gene_A0A9L0R207 | 252 | 118 | 249/252 | [(107, 'DLDET')] |
| horse_CTDSP2gene_A0A9L0T5X1 | 312 | 0 | 248/258 | [(148, 'DLDET')] |

## Placement of the full-length horse product A0A9L0T5X1

Pairwise identity over the catalytic region (from 10 residues before the first DxDx(T/V) motif to the C-terminus), ranked:

| Comparator | Identity |
|---|---|
| horse_CTDSP2gene_A0A9L0R207 | 1.0 |
| cow_CTDSP2_Q2KJ43 | 1.0 |
| human_CTDSP2_O14595 | 0.994 |
| mouse_Ctdsp2_Q8BX07 | 0.966 |
| human_CTDSPL_O15194 | 0.811 |
| mouse_Ctdsp1_P58466 | 0.783 |
| human_CTDSP1_Q9GZU7 | 0.783 |
| horse_CTDSP1_F6Q9M8 | 0.783 |

Neighbour-joining tree (rooted on human CTDSPL):

```
(((((cow_CTDSP2_Q2KJ43:-0.00020,(horse_CTDSP2gene_A0A9L0R207:-0.00259,human_CTDSP2_O14595:0.00259)Inner5:0.00306)Inner6:0.00020,horse_CTDSP2gene_A0A9L0T5X1:-0.00020)Inner7:0.01735,mouse_Ctdsp2_Q8BX07:0.01778)Inner4:0.09079,(horse_CTDSP1_F6Q9M8:0.00000,(mouse_Ctdsp1_P58466:0.00000,human_CTDSP1_Q9GZU7:0.00000)Inner1:0.00000)Inner2:0.10764)Inner3:0.08093,human_CTDSPL_O15194:0.00000):0.00000;
```