id: A0A9L0T837
gene_symbol: DNMT3L
taxon:
  id: NCBITaxon:9796
  label: Equus caballus
status: COMPLETE
description: Nuclear expression-regulatory functions are supported by conserved DNMT3L biology; the expression-regulation
  prediction is less precise than existing horse annotation.
source_documents:
- projects/PROTNLM_EVALUATION/mammal-benchmark/horse40-predictions.csv
- projects/PROTNLM_EVALUATION/mammal-benchmark/predictions.jsonl.gz
- projects/PROTNLM_EVALUATION/mammal-benchmark/paired-sequences/DNMT3L.json
references:
- id: PMID:12202768
  title: Dnmt3L is a transcriptional repressor that recruits histone deacetylase.
  full_text_unavailable: true
  findings: []
- id: file:HORSE/DNMT3L/DNMT3L-bioinformatics/RESULTS.md
  title: HORSE/DNMT3L/DNMT3L-bioinformatics/RESULTS.md
  findings: []
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  predicted_term:
    id: GO:0005634
    label: nucleus
  predicted_term_type: GO_CC
  review:
    assessment: CNN
    confidence_score: 2
    summary: Nuclear localization is supported by DNMT3L-dependent repression and recruitment of HDAC
      activity from nuclear extracts. The horse sequence aligns across the full human protein, retaining
      its ADD and methyltransferase-like interaction architecture, with an N-terminal extension. Nucleus
      already appears in frozen horse GOA; this is a supported conserved localization, not a catalytic
      methyltransferase assertion.
    supported_by:
    - &id001
      reference_id: PMID:12202768
      supporting_text: 'We find that Dnmt3L can repress transcription and that this repression is

        dependent on HDAC1 and is relieved by treatment with the HDAC inhibitor

        trichostatin A.'
    - reference_id: file:HORSE/DNMT3L/DNMT3L-bioinformatics/RESULTS.md
      supporting_text: share 77.7% identity among 386 paired residues. Paired coverage is 100.0% of human
        and 90.6% of horse.
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  predicted_term:
    id: GO:0010468
    label: regulation of gene expression
  predicted_term_type: GO_BP
  review:
    assessment: LSP
    confidence_score: 2
    summary: Human experiments establish DNMT3L-mediated transcriptional repression dependent on HDAC1,
      and the conserved horse protein retains the relevant domain architecture. The frozen horse GOA already
      contains negative regulation of gene expression, epigenetic, which is more specific than this broad
      regulation-of-gene-expression prediction. DNMT3L need not methylate DNA itself to regulate expression.
    supported_by:
    - *id001
    - reference_id: file:HORSE/DNMT3L/DNMT3L-bioinformatics/RESULTS.md
      supporting_text: share 77.7% identity among 386 paired residues. Paired coverage is 100.0% of human
        and 90.6% of horse.