# DUOX1 horse gene models vs human Q9NRD9 (re-review)

Generated by `compare_horse_models_rereview.py` from live UniProt (gene DUOX1 or PANTHER PTHR11972:SF75, taxon 9796) and Ensembl (ENSECAG00000023918) queries. Human reference Q9NRD9-1, 1551 aa; human features from the cached UniProt flat file.

| Accession | Length | PANTHER | Ensembl transcript | Ensembl canonical | Identity (paired) | Human span | Internal human gaps | Conserved binding residues |
|---|---|---|---|---|---|---|---|---|
| F6YEX2 | 1516 | PTHR11972:SF75;PTHR11972 | ENSECAT00000026134 | True | 91.4% | 1-1516 | none | Ca(2+) 15/15; heme 13/13; FAD 8/8; NADPH 6/11 |
| A0A9L0SA70 | 1508 | PTHR11972:SF75;PTHR11972 | ENSECAT00000094364 | False | 92.0% | 1-1551 | 940-940; 963-1004 | Ca(2+) 15/15; heme 13/13; FAD 8/8; NADPH 11/11 |
| A0A9L0SBC0 | 1505 | PTHR11972:SF75;PTHR11972 | ENSECAT00000113645 | False | 91.8% | 1-1551 | 561-606 | Ca(2+) 15/15; heme 13/13; FAD 8/8; NADPH 11/11 |
| A0A9L0SQG9 | 1452 | PTHR11972:SF75;PTHR11972 | ENSECAT00000123284 | False | 91.4% | 1-1551 | 775-873 | Ca(2+) 6/15; heme 13/13; FAD 8/8; NADPH 11/11 |

## Fraction of each human feature present per horse product

| Human feature | F6YEX2 | A0A9L0SA70 | A0A9L0SBC0 | A0A9L0SQG9 |
|---|---|---|---|---|
| TM helix 1 (592-616) | 1.00 | 1.00 | 0.40 | 1.00 |
| TM helix 2 (1044-1066) | 1.00 | 1.00 | 1.00 | 1.00 |
| TM helix 3 (1081-1105) | 1.00 | 1.00 | 1.00 | 1.00 |
| TM helix 4 (1128-1152) | 1.00 | 1.00 | 1.00 | 1.00 |
| TM helix 5 (1185-1210) | 1.00 | 1.00 | 1.00 | 1.00 |
| TM helix 6 (1223-1241) | 1.00 | 1.00 | 1.00 | 1.00 |
| TM helix 7 (1249-1262) | 1.00 | 1.00 | 1.00 | 1.00 |
| EF-hand 1 (815-850) | 1.00 | 1.00 | 1.00 | 0.00 |
| EF-hand 2 (851-886) | 1.00 | 1.00 | 1.00 | 0.36 |
| EF-hand 3 (895-930) | 1.00 | 1.00 | 1.00 | 1.00 |
| Ferric oxidoreductase (1096-1236) | 1.00 | 1.00 | 1.00 | 1.00 |
| FAD-binding FR-type (1270-1376) | 1.00 | 1.00 | 1.00 | 1.00 |
| Peroxidase-like (26-593) | 1.00 | 1.00 | 0.94 | 1.00 |
| Disordered (150-172) | 1.00 | 1.00 | 1.00 | 1.00 |
| Interaction with TXNDC11 (956-1248) | 1.00 | 0.86 | 1.00 | 1.00 |

## Coding-exon lengths (nt) per Ensembl transcript

- ENSECAT00000113645 (canonical=False, biotype=protein_coding, 1505 aa): [58, 84, 165, 188, 202, 167, 61, 97, 91, 103, 173, 176, 119, 114, 200, 186, 226, 94, 176, 70, 126, 179, 231, 100, 50, 128, 154, 233, 159, 156, 129, 123]
- ENSECAT00000123284 (canonical=False, biotype=protein_coding, 1452 aa): [58, 84, 165, 188, 202, 167, 61, 97, 91, 103, 173, 176, 119, 138, 114, 200, 186, 23, 176, 70, 126, 179, 231, 100, 50, 128, 154, 233, 159, 156, 129, 123]
- ENSECAT00000026134 (canonical=True, biotype=protein_coding, 1516 aa): [58, 84, 165, 188, 202, 167, 61, 97, 91, 103, 173, 176, 119, 138, 114, 200, 186, 226, 94, 176, 70, 126, 179, 231, 100, 50, 128, 154, 233, 159, 156, 129, 18]
- ENSECAT00000094364 (canonical=False, biotype=protein_coding, 1508 aa): [58, 84, 165, 188, 202, 167, 61, 97, 91, 103, 173, 176, 119, 138, 114, 200, 186, 226, 94, 176, 67, 179, 231, 100, 50, 128, 154, 233, 159, 156, 129, 123]