Gene Description

Equ c 2 (isoform 2.0101), a secreted horse dander lipocalin (calycin superfamily, lipocalin family) and allergen. As a secretory lipocalin it is expected to bind a small hydrophobic ligand in its beta-barrel calyx, but the specific endogenous ligand and physiological role are not established (the protein was characterized largely at the protein-sequence/allergen level).

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0005576 extracellular region	IEA GO_REF:0000044	ACCEPT	Summary: Equ c 2 is a secreted dander lipocalin; extracellular localization is appropriate. Reason: Secretory lipocalin acting in the extracellular space. Supporting Evidence: file:HORSE/Equc2/Equc2-uniprot.txt SUBCELLULAR LOCATION: Secreted

Core Functions

Secreted dander lipocalin (calyx fold) of the horse, expected by family analogy to bind a small hydrophobic ligand in its beta-barrel calyx; the specific molecular function, endogenous ligand and physiological role are not established. Unlike its paralog Equ c 1, Equ c 2 carries no phylogenetic (IBA) odorant-binding annotation, so a specific molecular-function term is not asserted here.

Cellular Locations:

extracellular region

References

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Suggested Experiments

Experiment: Identify co-purifying ligands of native Equ c 2 by LC-MS and test candidate ligands against recombinant protein by fluorescent-probe displacement.

Hypothesis: Equ c 2 binds a specific small hydrophobic ligand in its lipocalin calyx.

Type: ligand identification / biophysical binding assay

📚 Additional Documentation

Notes

(Equc2-notes.md)

Equc2 — curation notes (ALLERGENS backlog, mammalian inhalant cohort)

Equ c 2, horse dander lipocalin; only extracellular region in GOA; added NEW small molecule binding (lipocalin ligand, generic); ligand unknown -> function gap.

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