ID A0A9L0R5P7_HORSE Unreviewed; 1433 AA. AC A0A9L0R5P7; DT 13-SEP-2023, integrated into UniProtKB/TrEMBL. DT 13-SEP-2023, sequence version 1. DT 02-SEP-2026, entry version 15. DE RecName: Full=Gem-associated protein 5 {ECO:0000256|ARBA:ARBA00067669}; GN Name=GEMIN5 {ECO:0000313|Ensembl:ENSECAP00000056962.1}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000056962.1, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000056962.1, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000056962.1, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O., RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T., RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T., RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S., RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G., RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R., RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000056962.1} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000056962.1}; RG Ensembl; RL Submitted (JAN-2026) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. CC Nucleus, gem {ECO:0000256|ARBA:ARBA00034695}. Nucleus, nucleoplasm CC {ECO:0000256|ARBA:ARBA00004642}. CC -!- SIMILARITY: Belongs to the WD repeat gemin-5 family. CC {ECO:0000256|ARBA:ARBA00060968}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSECAT00000103662.1; ENSECAP00000056962.1; ENSECAG00000020479.3. DR GeneTree; ENSGT00620000088064; -. DR Proteomes; UP000002281; Chromosome 14. DR ExpressionAtlas; A0A9L0R5P7; baseline. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0097504; C:Gemini of Cajal bodies; IEA:UniProtKB-SubCell. DR GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:UniProtKB-ARBA. DR FunFam; 2.130.10.10:FF:000213; gem-associated protein 5 isoform X1; 1. DR FunFam; 2.130.10.10:FF:000221; gem-associated protein 5 isoform X1; 1. DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2. DR InterPro; IPR056432; Beta-prop_GEMI5_1st. DR InterPro; IPR056424; Beta-prop_GEMI5_2nd. DR InterPro; IPR056420; GEMI5_RBS. DR InterPro; IPR052640; Gemin-5. DR InterPro; IPR056421; TPR_GEMI5. DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf. DR InterPro; IPR020472; WD40_PAC1. DR InterPro; IPR019775; WD40_repeat_CS. DR InterPro; IPR036322; WD40_repeat_dom_sf. DR InterPro; IPR001680; WD40_rpt. DR PANTHER; PTHR46362; GEM-ASSOCIATED PROTEIN 5; 1. DR PANTHER; PTHR46362:SF1; GEM-ASSOCIATED PROTEIN 5; 1. DR Pfam; PF23770; Beta-prop_RIG_1st; 1. DR Pfam; PF23775; Beta-prop_RIG_2nd; 1. DR Pfam; PF23777; GEMI5_RBS; 1. DR Pfam; PF23774; TPR_GEMI5; 1. DR Pfam; PF00400; WD40; 1. DR PRINTS; PR00320; GPROTEINBRPT. DR SMART; SM00320; WD40; 13. DR SUPFAM; SSF50978; WD40 repeat-like; 2. DR PROSITE; PS00678; WD_REPEATS_1; 1. DR PROSITE; PS50082; WD_REPEATS_2; 3. DR PROSITE; PS50294; WD_REPEATS_REGION; 2. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|ARBA:ARBA00023054}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499}; KW mRNA processing {ECO:0000256|ARBA:ARBA00022664}; KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}; KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}; KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}; KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE- KW ProRule:PRU00221}. FT REPEAT 60..104 FT /note="WD" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221" FT DOMAIN 80..219 FT /note="Gem-associated protein 5 first beta-propeller" FT /evidence="ECO:0000259|Pfam:PF23770" FT REPEAT 241..264 FT /note="WD" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221" FT DOMAIN 389..701 FT /note="Gem-associated protein 5 second beta-propeller" FT /evidence="ECO:0000259|Pfam:PF23775" FT REPEAT 635..668 FT /note="WD" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221" FT DOMAIN 818..1026 FT /note="Gem-associated protein 5 TPR" FT /evidence="ECO:0000259|Pfam:PF23774" FT DOMAIN 1081..1419 FT /note="Gem-associated protein 5 RBS" FT /evidence="ECO:0000259|Pfam:PF23777" FT REGION 1237..1271 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1311..1359 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1315..1324 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1335..1345 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1433 AA; 159528 MW; FC21ABC729C0814E CRC64; MGQEPRTLPP SPNWYCARCS DAVPGGLFGF AARTSVFLVR VGPGAGAIPG TPPFRVIGEL VGHTERVSGF TFSHHPGQYN LCATSSDDGT VKIWDVETKT VVTEHALHQH TISALHWSPR VKDLIVSGDE KGVVFCYWLN RNDSQQLSVE PRTIFCLTCS PHDEDLVAIG YKDGIVVIID ISKKGEVIHR LRGHDDEIHS IAWCPLPGED CLSINQEENS EEPEIPNGKV IAQTPVTKGC YLATGSKDQT IRIWSCSRGR GVMILKLPVL KRRGGGIDPT VKERLWLTLH WPKNQPTQLV SSCLGGELLL WDLTQSWRRK FTVFSASSEG QNHSRIVFNL CPLHTEDDKQ LLLSTSMDRD VKCWDMATLE CCWTLPSLGG FAYSLAFSPV DTGSLAIGVG DGMIRIWNTL SIKNNYDVKN FWQGVKSKVT ALSWHPTKEG CLAFGTDDGK VGLYDTYSNK PPQISSTYHK KTVYTLAWGP PVPPLSLGGE GDRPSLTLYS CGGEGIVLQH NPWKLSGEAF DINKLIRDTN SIKYKLPVHT EISWKADGKI MALGNEDGSI EIFQVPNLKL ICTIQQHHKL VNTISWHHEH GSQPELSYLM ASGSNNAVIY VHNLKTVIES NPESPVTITE PYRTLSGHTA RITSLVWSPH HDGRLVSASY DGTAQVWDAL QEEPVCNFRG HRGRLFCVAW SPLDPDCIYS GADDFCVYKW LTSMQEHSRP PQVSRESVIC TPVSLGFEKS KVTANNKVTL PKKETPKEKP EAFIKKRKAR SMLPLSTSLD HRSKEELHRD CLVLATAKHS TAELNEDVSA DLEERFHLGL FTDRTTLYRM IEVEGKGHLE NGHPELFHQL MLWKGDLKGV LQTAAERGEL TDNLVAMAPV AGYHVWVWAV EAFAKQLCFQ DQYVKAASHL LSIHKVYEAV ELLKSNHFYR EAIAVAKARL RPEDPILKDL YLSWGAILEK DGHYAVAAKC YLGATSAYDA AKVLAKKGDT ASLRTAAELA SIVGENELSS SLALRCAQEL LLARNWVGAQ EALQLHASLK GQRLVFCLLE LLSQHLEEKQ VPEGRSPPSH NAWATSIEGP FVERVTAVWK SAFGLDTPQQ HQTAFQQLQN IKYPSATNNT PSKQLLLHMC HDLTLAVLSQ QMASWDAAVE ALLRAVVRSY DSGNFTIMQE VHAAFLPKGC DPLRDKLSDC QSAATPAFKS LEAFFIYGRL YEFWWSLSRP CPKSSVWVRA GDGRMASVEQ SQQLADANPK ETDPKAQAEP SRPPAPDVEL TEENEQILNA CKELFSEKHA SFQNAQRTVA EVQETLAEMI RQHQKSQLGK STANGPDKNE PGQEAEQSLS SPQSQCKEEK NEQVSLPELT RRLTEANERI AKFPESIKTW PFPDVLECCL VLLHIGSQRP GRVPQEVQQQ AQALLQKYGS TKVYKRHCQA FCT //