ID   F6WDM0_HORSE            Unreviewed;      1517 AA.
AC   F6WDM0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 3.
DT   02-SEP-2026, entry version 77.
DE   RecName: Full=Gem-associated protein 5 {ECO:0000256|ARBA:ARBA00067669};
GN   Name=GEMIN5 {ECO:0000313|Ensembl:ENSECAP00000018265.3,
GN   ECO:0000313|VGNC:VGNC:18304};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000018265.3, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000018265.3, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018265.3,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000018265.3}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018265.3};
RG   Ensembl;
RL   Submitted (JAN-2026) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus, gem {ECO:0000256|ARBA:ARBA00034695}. Nucleus, nucleoplasm
CC       {ECO:0000256|ARBA:ARBA00004642}.
CC   -!- SIMILARITY: Belongs to the WD repeat gemin-5 family.
CC       {ECO:0000256|ARBA:ARBA00060968}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   FunCoup; F6WDM0; 3544.
DR   STRING; 9796.ENSECAP00000018265; -.
DR   PaxDb; 9796-ENSECAP00000018265; -.
DR   Ensembl; ENSECAT00000022126.3; ENSECAP00000018265.3; ENSECAG00000020479.3.
DR   VGNC; VGNC:18304; GEMIN5.
DR   GeneTree; ENSGT00620000088064; -.
DR   InParanoid; F6WDM0; -.
DR   Proteomes; UP000002281; Chromosome 14.
DR   Bgee; ENSECAG00000020479; Expressed in trophectoderm and 23 other cell types or tissues.
DR   ExpressionAtlas; F6WDM0; baseline.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0097504; C:Gemini of Cajal bodies; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0032797; C:SMN complex; IBA:GO_Central.
DR   GO; GO:0034718; C:SMN-Gemin2 complex; IEA:Ensembl.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR   GO; GO:0043022; F:ribosome binding; IEA:Ensembl.
DR   GO; GO:0000340; F:RNA 7-methylguanosine cap binding; IEA:Ensembl.
DR   GO; GO:0030619; F:U1 snRNA binding; IEA:Ensembl.
DR   GO; GO:0030621; F:U4 snRNA binding; IEA:Ensembl.
DR   GO; GO:0030622; F:U4atac snRNA binding; IEA:Ensembl.
DR   GO; GO:0006417; P:regulation of translation; IEA:Ensembl.
DR   GO; GO:0000387; P:spliceosomal snRNP assembly; IBA:GO_Central.
DR   FunFam; 2.130.10.10:FF:000213; gem-associated protein 5 isoform X1; 1.
DR   FunFam; 2.130.10.10:FF:000221; gem-associated protein 5 isoform X1; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR056432; Beta-prop_GEMI5_1st.
DR   InterPro; IPR056424; Beta-prop_GEMI5_2nd.
DR   InterPro; IPR056420; GEMI5_RBS.
DR   InterPro; IPR052640; Gemin-5.
DR   InterPro; IPR056421; TPR_GEMI5.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR020472; WD40_PAC1.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR46362; GEM-ASSOCIATED PROTEIN 5; 1.
DR   PANTHER; PTHR46362:SF1; GEM-ASSOCIATED PROTEIN 5; 1.
DR   Pfam; PF23770; Beta-prop_RIG_1st; 1.
DR   Pfam; PF23775; Beta-prop_RIG_2nd; 1.
DR   Pfam; PF23777; GEMI5_RBS; 1.
DR   Pfam; PF23774; TPR_GEMI5; 1.
DR   Pfam; PF00400; WD40; 1.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 13.
DR   SUPFAM; SSF50978; WD40 repeat-like; 2.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW   mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   REPEAT          60..104
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          80..219
FT                   /note="Gem-associated protein 5 first beta-propeller"
FT                   /evidence="ECO:0000259|Pfam:PF23770"
FT   REPEAT          241..264
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          389..710
FT                   /note="Gem-associated protein 5 second beta-propeller"
FT                   /evidence="ECO:0000259|Pfam:PF23775"
FT   REPEAT          644..677
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          902..1110
FT                   /note="Gem-associated protein 5 TPR"
FT                   /evidence="ECO:0000259|Pfam:PF23774"
FT   DOMAIN          1165..1503
FT                   /note="Gem-associated protein 5 RBS"
FT                   /evidence="ECO:0000259|Pfam:PF23777"
FT   REGION          726..803
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1321..1355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1395..1443
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        748..757
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1399..1408
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1419..1429
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1517 AA;  168820 MW;  FD199965CC38563F CRC64;
     MGQEPRTLPP SPNWYCARCS DAVPGGLFGF AARTSVFLVR VGPGAGAIPG TPPFRVIGEL
     VGHTERVSGF TFSHHPGQYN LCATSSDDGT VKIWDVETKT VVTEHALHQH TISALHWSPR
     VKDLIVSGDE KGVVFCYWLN RNDSQQLSVE PRTIFCLTCS PHDEDLVAIG YKDGIVVIID
     ISKKGEVIHR LRGHDDEIHS IAWCPLPGED CLSINQEENS EEPEIPNGKV IAQTPVTKGC
     YLATGSKDQT IRIWSCSRGR GVMILKLPVL KRRGGGIDPT VKERLWLTLH WPKNQPTQLV
     SSCLGGELLL WDLTQSWRRK FTVFSASSEG QNHSRIVFNL CPLHTEDDKQ LLLSTSMDRD
     VKCWDMATLE CCWTLPSLGG FAYSLAFSPV DTGSLAIGVG DGMIRIWNTL SIKNNYDVKN
     FWQGVKSKVT ALSWHPTKEG CLAFGTDDGK VGLYDTYSNK PPQISSTYHK KTVYTLAWGP
     PVPPLSLGGE GDRPSLTLYS CGGEGIVLQH NPWKLSGEAF DINKLIRDTN SIKYKLPVHT
     EISWKADGKI MALGNEDGSI EIFQVPNLKL ICTIQQHHKL VNTISWHHEH GSQPELSYLM
     ASGSNNAVIY VHNLKTVIEM TSSPCLVESN PESPVTITEP YRTLSGHTAR ITSLVWSPHH
     DGRLVSASYD GTAQVWDALQ EEPVCNFRGH RGRLFCVAWS PLDPDCIYSG ADDFCVYKWL
     TSMQEHSRPP QGKKSIELEK KRLSQPKPKP KKKKKLTSRV PVKQELCDGN EEESTRESSG
     PVENGVSDQE AEEEAREPEL PCEVASAVSR ESVICTPVSL GFEKSKVTAN NKVTLPKKET
     PKEKPEAFIK KRKARSMLPL STSLDHRSKE ELHRDCLVLA TAKHSTELNE DVSADLEERF
     HLGLFTDRTT LYRMIEVEGK GHLENGHPEL FHQLMLWKGD LKGVLQTAAE RGELTDNLVA
     MAPVAGYHVW VWAVEAFAKQ LCFQDQYVKA ASHLLSIHKV YEAVELLKSN HFYREAIAVA
     KARLRPEDPI LKDLYLSWGA ILEKDGHYAV AAKCYLGATS AYDAAKVLAK KGDTASLRTA
     AELASIVGEN ELSSSLALRC AQELLLARNW VGAQEALQLH ASLKGQRLVF CLLELLSQHL
     EEKQVPEGRS PPSHNAWATS IEGPFVERVT AVWKSAFGLD TPQQHQTAFQ QLQNIKYPSA
     TNNTPSKQLL LHMCHDLTLA VLSQQMASWD AAVEALLRAV VRSYDSGNFT IMQEVHAAFL
     PKGCDPLRDK LSDCQSAATP AFKSLEAFFI YGRLYEFWWS LSRPCPKSSV WVRAGDGRMA
     SVEQSQQLAD ANPKETDPKA QAEPSRPPAP DVELTEENEQ ILNACKELFS EKHASFQNAQ
     RTVAEVQETL AEMIRQHQKS QLGKSTANGP DKNEPGQEAE QSLSSPQSQC KEEKNEQVSL
     PELTRRLTEA NERIAKFPES IKTWPFPDVL ECCLVLLHIG SQRPGRVPQE VQQQAQALLQ
     KYGSTKVYKR HCQAFCT
//