ProtNLM2 External predictions
View prediction review YAML · PEA15-protnlm-predictions-review.yaml · Review status: COMPLETE
PEA15 has experimentally supported regulatory effects on glucose-transporter trafficking. Whether the exact carbohydrate-transport process annotation is justified for the selected horse protein remains uncertain.
Source documents: genes/HORSE/PEA15/PEA15-bioinformatics/RESULTS.md · genes/human/PEA15/PEA15-uniprot.txt · publications/PMID_9670003.md
Review score: 2 = concordant with evidence; 1 = uncertain; 0 = discordant with evidence. This is an assessment score, not a model probability.
UNC — Uncertain Review score: 1/2
Prediction method: ProtNLM2 · Version: UniProt API snapshot 2026-09-08
Review rationale: Human PEA15 changes GLUT1/GLUT4 surface recruitment and insulin-stimulated glucose transport, so this prediction must not be rejected merely because PEA15 lacks a transporter fold. The selected horse protein retains the complete human core at 100% identity with a 46-residue N-terminal extension. However, the inspected experimental evidence supports regulation of transport, whereas GO:0008643 denotes directed carbohydrate movement; regulation is not automatically the same biological-process assertion. The exact horse process has no target GOA overlap and neither direct horse transport evidence nor a demonstrated mechanistic participation beyond regulation is available. The prediction remains uncertain rather than being classified as a nonparalog error.
Supporting Evidence:
- PMID:9670003: "Transfection of PED/PEA-15 in differentiating L6 skeletal muscle cells increases the content of Glut1 transporters on the plasma membrane and inhibits insulin-stimulated glucose transport and cell-surface recruitment of Glut4"
- file:HORSE/PEA15/PEA15-bioinformatics/RESULTS.md: "Global alignment of cached UniProt sequences gives **130/130 identical paired residues (100.0%)**."