id: A0A9L0RWM8
gene_symbol: PEA15
taxon:
  id: NCBITaxon:9796
  label: Equus caballus
status: COMPLETE
description: PEA15 has experimentally supported regulatory effects on glucose-transporter trafficking.
  Whether the exact carbohydrate-transport process annotation is justified for the selected horse protein
  remains uncertain.
source_documents:
- genes/HORSE/PEA15/PEA15-bioinformatics/RESULTS.md
- genes/human/PEA15/PEA15-uniprot.txt
- publications/PMID_9670003.md
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  predicted_term:
    id: GO:0008643
    label: carbohydrate transport
  predicted_term_type: GO_BP
  review:
    assessment: UNC
    confidence_score: 1
    summary: Human PEA15 changes GLUT1/GLUT4 surface recruitment and insulin-stimulated glucose transport,
      so this prediction must not be rejected merely because PEA15 lacks a transporter fold. The selected
      horse protein retains the complete human core at 100% identity with a 46-residue N-terminal extension.
      However, the inspected experimental evidence supports regulation of transport, whereas GO:0008643
      denotes directed carbohydrate movement; regulation is not automatically the same biological-process
      assertion. The exact horse process has no target GOA overlap and neither direct horse transport
      evidence nor a demonstrated mechanistic participation beyond regulation is available. The prediction
      remains uncertain rather than being classified as a nonparalog error.
    supported_by:
    - reference_id: PMID:9670003
      supporting_text: 'Transfection of PED/PEA-15 in

        differentiating L6 skeletal muscle cells increases the content of Glut1

        transporters on the plasma membrane and inhibits insulin-stimulated glucose

        transport and cell-surface recruitment of Glut4'
    - reference_id: file:HORSE/PEA15/PEA15-bioinformatics/RESULTS.md
      supporting_text: Global alignment of cached UniProt sequences gives **130/130 identical paired residues
        (100.0%)**.
references:
- id: PMID:9670003
  title: PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus.
- id: file:HORSE/PEA15/PEA15-bioinformatics/RESULTS.md
  title: PEA15 human–horse sequence comparison