ID   A0A9L0RGD6_HORSE        Unreviewed;       883 AA.
AC   A0A9L0RGD6;
DT   13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 1.
DT   10-JUN-2026, entry version 14.
DE   SubName: Full=Shieldin complex subunit 2 {ECO:0000313|Ensembl:ENSECAP00000060865.1};
GN   Name=SHLD2 {ECO:0000313|Ensembl:ENSECAP00000060865.1};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000060865.1, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000060865.1, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000060865.1,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000060865.1}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000060865.1};
RG   Ensembl;
RL   Submitted (JAN-2026) to UniProtKB.
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DR   AlphaFoldDB; A0A9L0RGD6; -.
DR   Ensembl; ENSECAT00000102809.1; ENSECAP00000060865.1; ENSECAG00000001626.3.
DR   GeneTree; ENSGT00390000003133; -.
DR   Proteomes; UP000002281; Chromosome 1.
DR   InterPro; IPR029715; FAM35A.
DR   InterPro; IPR031589; SHLD2_C.
DR   InterPro; IPR049507; SHLD2_OB1.
DR   InterPro; IPR053944; SHLD2_OB2.
DR   PANTHER; PTHR14495; SHIELDIN COMPLEX SUBUNIT 2; 1.
DR   PANTHER; PTHR14495:SF2; SHIELDIN COMPLEX SUBUNIT 2; 1.
DR   Pfam; PF22779; OB_SHLD2_2nd; 1.
DR   Pfam; PF15793; SHLD2_C; 1.
DR   Pfam; PF21669; SHLD2_OB1; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   DOMAIN          430..563
FT                   /note="Shieldin complex subunit 2 first OB fold"
FT                   /evidence="ECO:0000259|Pfam:PF21669"
FT   DOMAIN          595..676
FT                   /note="Shieldin complex subunit 2 second OB fold"
FT                   /evidence="ECO:0000259|Pfam:PF22779"
FT   DOMAIN          733..804
FT                   /note="Shieldin complex subunit 2 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF15793"
FT   REGION          862..883
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        871..883
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   883 AA;  98885 MW;  B11E6202A74C26C2 CRC64;
     MSGGSQVHIF WGAPIGPLKM TVSQEPTSLV STTDPWKKIQ LLYNQHSLHL KDDKCKHKNL
     EDCQVLDAAG PSDLLNGHFL ANSVNRSAHV KDDFVHCISE TETTKSHKIP PLEMSGIPNS
     DVQICGFKGR VQHLTEEEKC QQLFSENKKI ADEQHKDQSN ICGQNFPKNS LHLDPKCAAI
     LDLVCGTEQI NIGPGAAETK RVPTGHRERQ TQRLEFFPSS TVDEPRSERA ARKDSALNIS
     TDTEFLSVMT SSQVAFLAQR KYKGQNSVNK GIVNMEIEPK ASHGEMRKRE DNLIKPNDGF
     AEGSESGQTE AYSLELFSPV CPETESSNIR INSDKGLEEN TGSQELFTFE NKLLPDEICI
     ESCSSGILCS QGNTFLKSSG KRNRTSEDKL GHSKALSKVL QESKKMKLVS NARDPPVEMG
     QRNVSKFHGV KKTSLIKNCG SKSQKYNCLV MVLSPCHVKE INIKSGPNSG SKVPLATITV
     IDQSEVKKKV FLWRTAAFWA FTVFLGDIVL LTDVTIHDDH WVGERVLQST FTSQLLNLGS
     YSSVQPEEYS SMVSDVVLQD LLAYVSSKHS YLKDLPQRRP QKMNSIEFVE LACLRPDILV
     HAVVRVVDIT VLTEAVYSYR GQKQRKVMLT VEQTQGQHYV LVLWGPGAAW YPQLQRKKDY
     IWEFKYLFVQ RNCVLENLEL HTTPWSSCES LFDDDIRAVT FKAKFQKSTS SFVKMSDLAV
     HLEDKCSGVI LIKAQILELV FPTTAAQKIA LNARSSLKSI FSSLPNIVYT GCAKCGLELE
     TDENRIYRQC FSCLPFTMKK IYYSAPRRGH LWHGRRRLAP RLAGGRRGPL CGEGAEPLPA
     GRKQLPPATG FLAPRLLPRQ CEPASQAFPE TRGKNCRRFE DNP
//