ID   A0A9L0TUF0_HORSE        Unreviewed;      1047 AA.
AC   A0A9L0TUF0;
DT   13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 1.
DT   10-JUN-2026, entry version 14.
DE   SubName: Full=Shieldin complex subunit 2 {ECO:0000313|Ensembl:ENSECAP00000090394.1};
GN   Name=SHLD2 {ECO:0000313|Ensembl:ENSECAP00000090394.1};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000090394.1, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000090394.1, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000090394.1,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000090394.1}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000090394.1};
RG   Ensembl;
RL   Submitted (JAN-2026) to UniProtKB.
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DR   AlphaFoldDB; A0A9L0TUF0; -.
DR   Ensembl; ENSECAT00000122467.1; ENSECAP00000090394.1; ENSECAG00000001626.3.
DR   GeneTree; ENSGT00390000003133; -.
DR   Proteomes; UP000002281; Chromosome 1.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0035861; C:site of double-strand break; IBA:GO_Central.
DR   GO; GO:2000042; P:negative regulation of double-strand break repair via homologous recombination; IEA:Ensembl.
DR   GO; GO:2001034; P:positive regulation of double-strand break repair via nonhomologous end joining; IEA:Ensembl.
DR   GO; GO:0045830; P:positive regulation of isotype switching; IEA:Ensembl.
DR   GO; GO:0010569; P:regulation of double-strand break repair via homologous recombination; IBA:GO_Central.
DR   InterPro; IPR029715; FAM35A.
DR   InterPro; IPR031589; SHLD2_C.
DR   InterPro; IPR049507; SHLD2_OB1.
DR   InterPro; IPR053944; SHLD2_OB2.
DR   PANTHER; PTHR14495; SHIELDIN COMPLEX SUBUNIT 2; 1.
DR   PANTHER; PTHR14495:SF2; SHIELDIN COMPLEX SUBUNIT 2; 1.
DR   Pfam; PF22779; OB_SHLD2_2nd; 1.
DR   Pfam; PF15793; SHLD2_C; 1.
DR   Pfam; PF21669; SHLD2_OB1; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   DOMAIN          469..602
FT                   /note="Shieldin complex subunit 2 first OB fold"
FT                   /evidence="ECO:0000259|Pfam:PF21669"
FT   DOMAIN          634..715
FT                   /note="Shieldin complex subunit 2 second OB fold"
FT                   /evidence="ECO:0000259|Pfam:PF22779"
FT   DOMAIN          772..935
FT                   /note="Shieldin complex subunit 2 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF15793"
SQ   SEQUENCE   1047 AA;  116377 MW;  C920AEF4A08705F7 CRC64;
     MGSMGKREQS ERTPGVLACG TGRMELPFAE MSMTFYKETM SGGSQVHIFW GAPIGPLKMT
     VSQEPTSLVS TTDPWKKIQL LYNQHSLHLK DDKCKHKNLE DCQVLDAAGP SDLLNGHFLA
     NSVNRSAHVK DDFVHCISET ETTKSHKIPP LEMSGIPNSD VQICGFKGRV QHLTEEEKCQ
     QLFSENKKIA DEQHKDQSNI CGQNFPKNSL HLDPKCAAIL DLVCGTEQIN IGPGAAETKR
     VPTGHRERQT QRLEFFPSST VDEPRSERAA RKDSALNIST DTEFLSVMTS SQVAFLAQRK
     YKGQNSVNKG IVNMEIEPKA SHGEMRKRED NLIKPNDGFA EGSESGQTEA YSLELFSPVC
     PETESSNIRI NSDKGLEENT GSQELFTFEN KLLPDEICIE SCSSGILCSQ GNTFLKSSGK
     RNRTSEDKLG HSKALSKVLQ ESKKMKLVSN ARDPPVEMGQ RNVSKFHGVK KTSLIKNCGS
     KSQKYNCLVM VLSPCHVKEI NIKSGPNSGS KVPLATITVI DQSEVKKKVF LWRTAAFWAF
     TVFLGDIVLL TDVTIHDDHW VGERVLQSTF TSQLLNLGSY SSVQPEEYSS MVSDVVLQDL
     LAYVSSKHSY LKDLPQRRPQ KMNSIEFVEL ACLRPDILVH AVVRVVDITV LTEAVYSYRG
     QKQRKVMLTV EQTQGQHYVL VLWGPGAAWY PQLQRKKDYI WEFKYLFVQR NCVLENLELH
     TTPWSSCESL FDDDIRAVTF KAKFQKSTSS FVKMSDLAVH LEDKCSGVIL IKAQILELVF
     PTTAAQKIAL NARSSLKSIF SSLPNIVYTG CAKCGLELET DENRIYRQCF SCLPFTMKKI
     YYRPALMTIA DGIYKVCVHV GSQLIEKILL DISPDWLSRA IAPPAEVTYG MVAADLLHAL
     LAGGGAPCVV KVQSLFLLDE NSYPLQQDFS LLDFYPDNVS PPPRPSLRPG EKIAGASRTI
     PEMRNDLATQ AAHSRSLGIK GALFRLSHTP GDTLSPGDTD MRHSLRNGVS AVLTSSQLSH
     IPASLNHPRG MTLLVILHHI GLVHISP
//