id: A0A9L0T4E4
gene_symbol: ZDHHC23
taxon:
  id: NCBITaxon:9796
  label: Equus caballus
status: COMPLETE
description: Assessment of 1 ProtNLM GO predictions for the selected horse ZDHHC23 protein, using mammalian
  experimental findings and an explicit comparison of the horse sequence.
source_documents:
- genes/human/ZDHHC23/ZDHHC23-uniprot.txt
- genes/HORSE/ZDHHC23/ZDHHC23-bioinformatics/RESULTS.md
- projects/PROTNLM_EVALUATION/mammal-benchmark/horse40-predictions.csv
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-08
  predicted_term:
    id: GO:0019706
    label: protein-cysteine S-palmitoyltransferase activity
  predicted_term_type: GO_MF
  review:
    assessment: CNN
    confidence_score: 2
    summary: Human ZDHHC23-dependent KCNMA1 palmitoylation is experimentally supported (PMID:22399288).
      The horse sequence retains the DHHC catalytic cysteine (human289/horse283), with 91.07% identity
      over 98.53% of the human sequence. Transfer of protein-cysteine S-palmitoyltransferase activity
      is justified and agrees with the exact horse IBA/IEA term. This judgment rests on substrate experiments
      and sequence conservation, not ARBA agreement. Training-set membership is unknown.
    supported_by:
    - reference_id: file:human/ZDHHC23/ZDHHC23-uniprot.txt
      supporting_text: 'CC   -!- FUNCTION: Palmitoyltransferase that could catalyze the addition of

        CC       palmitate onto various protein substrates and be involved in a variety

        CC       of cellular processes (Probable). Palmitoyltransferase that mediates

        CC       palmitoylation of KCNMA1, regulating localization of KCNMA1 to the

        CC       plasma membrane. May be involved in NOS1 regulation and targeting to

        CC       the synaptic membrane. {ECO:0000269|PubMed:22399288,

        CC       ECO:0000305|PubMed:22399288}.'
    - reference_id: file:HORSE/ZDHHC23/ZDHHC23-bioinformatics/RESULTS.md
      supporting_text: The horse sequence A0A9L0T4E4 (448 residues) aligns to human Q8IYP9 (409 residues)
        with 91.07% identity across 403 paired residues. Paired coverage is 98.53% of the human sequence
        and 89.96% of the horse sequence.
    - reference_id: PMID:22399288
      supporting_text: 'Here, we demonstrate that

        palmitoylation of the intracellular S0-S1 loop of BK channels is controlled by

        two of the 23 mammalian palmitoyl-transferases, zDHHC22 and zDHHC23.

        Palmitoylation by these acyl transferases is essential for efficient cell

        surface expression of BK channels.'
references:
- id: file:human/ZDHHC23/ZDHHC23-uniprot.txt
  title: UniProt record for human ZDHHC23
  findings: []
- id: file:HORSE/ZDHHC23/ZDHHC23-bioinformatics/RESULTS.md
  title: "ZDHHC23: horse\u2013human sequence comparison"
  findings: []
- id: PMID:22399288
  title: Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated
    potassium channels.
  findings: []