id: A0A2K5UJ34
gene_symbol: A0A2K5UJ34
taxon:
  id: NCBITaxon:9541
  label: Macaca fascicularis
status: COMPLETE
description: >-
  TTC39C subfamily placement supports a family-based inference of a role in vertebrate heart left-right
  patterning through cilia.
source_documents:
  - genes/MACFA/A0A2K5UJ34/A0A2K5UJ34-uniprot.txt
  - genes/MACFA/A0A2K5UJ34/A0A2K5UJ34-goa.tsv
  - publications/PMID_25860617.md
predictions:
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0061371
      label: determination of heart left/right asymmetry
    predicted_term_type: GO_BP
    review:
      assessment: COR
      confidence_score: 2
      summary: >-
        The target is assigned specifically to the TTC39C subfamily rather than only to a generic TPR-repeat
        fold. Zebrafish ttc39c perturbation in a primary cilia study produced laterality defects, including
        abnormal heart positioning (PMID:25860617). Conservation of the TTC39C ciliary role and vertebrate
        cilia-dependent laterality provides a reasonable basis for transferring the broad heart-asymmetry
        process to macaque TTC39C. This is an ortholog-based inference rather than a macaque experiment;
        the process is absent from the cached target annotations.
      supported_by:
        - reference_id: file:MACFA/A0A2K5UJ34/A0A2K5UJ34-uniprot.txt
          supporting_text: >-
            ID   A0A2K5UJ34_MACFA        Unreviewed;       545 AA. ... DR   InterPro; IPR019412; IML2/TPR_39.
            ... DR   PANTHER; PTHR31859:SF1; TETRATRICOPEPTIDE REPEAT PROTEIN 39C; 1.
        - reference_id: PMID:25860617
          supporting_text: >-
            defective left-right patterning
references:
  - id: file:MACFA/A0A2K5UJ34/A0A2K5UJ34-uniprot.txt
    title: A0A2K5UJ34-uniprot.txt
  - id: PMID:25860617
    title: Characterization of tetratricopeptide repeat-containing proteins critical for cilia
      formation and function.