| Claim (function/localization/pathway) | Evidence summary | Organism/strain context | Source (with year, journal, URL) | Citation id |
|---|---|---|---|---|
| mxaG encodes cytochrome cL, the cognate electron acceptor associated with methanol dehydrogenase | Review text explicitly states that methylotrophic PQQ-dependent alcohol dehydrogenases are associated with cytochrome cL and names MxaG as the cytochrome cL partner; another source states that mxaG encodes cytochrome cL and identifies it as the primary electron acceptor in the MDH system. | Methylorubrum extorquens AM1 / historical Methylobacterium extorquens context | Roszczenko-Jasińska et al., 2020, *Scientific Reports*, https://doi.org/10.1038/s41598-020-69401-4; Purves, 2019, unknown journal, URL not available in retrieved record | (pqac-00000000, pqac-00000001, pqac-00000004) |
| Cytochrome cL functions in the periplasmic methanol-oxidation electron transfer chain | Evidence states methanol oxidation occurs in the periplasm via PQQ-dependent ADHs/MDH, and that the associated cytochrome cL transfers electrons from reduced PQQ to additional cytochromes in the electron transport chain. | Methylorubrum extorquens AM1 | Roszczenko-Jasińska et al., 2020, *Scientific Reports*, https://doi.org/10.1038/s41598-020-69401-4 | (pqac-00000000, pqac-00000001) |
| In Methylobacterium/Methylorubrum extorquens, mxaG is genetically part of the mxa methanol dehydrogenase cluster | The mxa operon is described as mxaFJGIRSACKLDEHB, placing mxaG within the canonical methanol dehydrogenase gene cluster and supporting its dedicated role in MDH function. | Methylorubrum extorquens AM1 | Roszczenko-Jasińska et al., 2020, *Scientific Reports*, https://doi.org/10.1038/s41598-020-69401-4 | (pqac-00000000) |
| Electron flow proceeds from MDH-reduced PQQ to cytochrome cL | A source describes that methanol oxidation by periplasmic MDH reduces PQQ, and the reduced PQQ is then reoxidized by transfer of two electrons to the heme of cytochrome cL. | Historical naming: Methylobacterium extorquens (same species complex as Methylorubrum extorquens) | Rojas, 2021, unknown journal, URL not available in retrieved record | (pqac-00000002, pqac-00000003) |
| Cytochrome cL passes electrons onward to downstream cytochromes/respiratory components | One source states cytochrome cL transfers electrons from PQQ to additional cytochromes in the electron transport chain; another states cytochrome cL is oxidized by cytochrome cH, linking methanol oxidation to respiration and energy conservation. | Methylorubrum extorquens AM1 / historical Methylobacterium extorquens context | Roszczenko-Jasińska et al., 2020, *Scientific Reports*, https://doi.org/10.1038/s41598-020-69401-4; Rojas, 2021, unknown journal, URL not available in retrieved record | (pqac-00000000, pqac-00000002, pqac-00000003) |
| Methanol oxidation enzymes and their cytochrome cL partner are localized in the periplasm | The evidence states that methylotrophic PQQ-ADHs are periplasmic and associated with cytochrome cL; a figure-based summary also depicts methanol oxidation in the periplasm by MxaFI/XoxF enzymes. | Methylorubrum extorquens AM1 | Roszczenko-Jasińska et al., 2020, *Scientific Reports*, https://doi.org/10.1038/s41598-020-69401-4 | (pqac-00000001, pqac-00000006) |
| The gathered literature supports mxaG as the relevant symbol; explicit use of the synonym moxG was not found in the retrieved evidence | Across the directly gathered evidence, the gene is referred to as mxaG encoding cytochrome cL; the retrieved texts did not explicitly mention the synonym moxG or UniProt P14774. | Methylorubrum extorquens AM1 / historical Methylobacterium extorquens context | Roszczenko-Jasińska et al., 2020, *Scientific Reports*, https://doi.org/10.1038/s41598-020-69401-4; Rojas, 2021, unknown journal, URL not available in retrieved record; Purves, 2019, unknown journal, URL not available in retrieved record | (pqac-00000000, pqac-00000001, pqac-00000002, pqac-00000003, pqac-00000004) |


*Table: This table summarizes directly supported functional annotation claims for Methylorubrum extorquens AM1 moxG/mxaG (cytochrome cL), including function, localization, and pathway role. It is useful as a traceable evidence map restricted to the gathered sources and context IDs.*