d8 - AI Gene Review

Core Functions

Represses gibberellin-responsive transcription as a nuclear DELLA-family regulator in GA signaling.

Molecular Function:

transcription corepressor activity

Directly Involved In:

gibberellic acid mediated signaling pathway

Cellular Locations:

nucleus

Supporting Evidence:

file:MISSI/d8/d8-uniprot.txt
Transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway.
file:MISSI/d8/d8-uniprot.txt
SUBCELLULAR LOCATION: Nucleus
file:MISSI/d8/d8-uniprot.txt
The DELLA motif is required for its GA-induced degradation.

References

file:MISSI/d8/d8-uniprot.txt

UniProtKB entry for Miscanthus sinensis d8

UniProt describes d8 as a DELLA protein that represses gibberellin signaling transcription and localizes to the nucleus.

Suggested Experiments

Experiment: Test GA-responsive reporter expression and growth phenotypes in Miscanthus d8 allelic or expression variants.

Type: targeted functional assay

📚 Additional Documentation

Notes

(d8-notes.md)

Curation notes

QuickGO export is header-only; therefore no UniProt DR/InterPro-derived terms are listed as existing_annotations or proposed as NEW.
Core function uses UniProt's DELLA/GRAS description to represent d8 as a nuclear transcriptional corepressor in gibberellin signaling.
UniProt flags this sequence as a fragment and cautions that conserved residues needed for feature propagation are missing; the core function is therefore treated as a family-supported DELLA inference that should be confirmed with a full-length Miscanthus sequence. This is also captured as a suggested question in the review.

📄 View Raw YAML

id: A0A0A0UMC1
gene_symbol: d8
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:62337
  label: Miscanthus sinensis
description: Fragmentary DELLA/GRAS transcriptional regulator that represses gibberellin-responsive transcription in the nucleus.
existing_annotations: []
references:
- id: file:MISSI/d8/d8-uniprot.txt
  title: UniProtKB entry for Miscanthus sinensis d8
  findings:
  - statement: UniProt describes d8 as a DELLA protein that represses gibberellin signaling transcription and localizes to the nucleus.
core_functions:
- description: Represses gibberellin-responsive transcription as a nuclear DELLA-family regulator in GA signaling.
  molecular_function:
    id: GO:0003714
    label: transcription corepressor activity
  directly_involved_in:
  - id: GO:0009740
    label: gibberellic acid mediated signaling pathway
  locations:
  - id: GO:0005634
    label: nucleus
  supported_by:
  - reference_id: file:MISSI/d8/d8-uniprot.txt
    supporting_text: Transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway.
  - reference_id: file:MISSI/d8/d8-uniprot.txt
    supporting_text: 'SUBCELLULAR LOCATION: Nucleus'
  - reference_id: file:MISSI/d8/d8-uniprot.txt
    supporting_text: The DELLA motif is required for its GA-induced degradation.
proposed_new_terms: []
suggested_questions:
- question: Does Miscanthus d8 variation alter gibberellin response, stem elongation, or biomass traits?
- question: Is the cached Miscanthus d8 sequence full length in the current assembly, or does the UniProt fragment status limit annotation confidence?
suggested_experiments:
- description: Test GA-responsive reporter expression and growth phenotypes in Miscanthus d8 allelic or expression variants.
  experiment_type: targeted functional assay

d8

Gene Description