id: Q1K6K5
gene_symbol: NCU01245
locus_tag: NCU01245
taxon:
  id: NCBITaxon:367110
  label: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
status: COMPLETE
description: NCU01245 is the conserved RPC4/C53 subunit of nuclear RNA polymerase III. It associates with
  the C37 subunit and supports promoter opening, transcription termination and polymerase recycling during
  synthesis of tRNAs and other polymerase III RNAs. Its role is structural and regulatory within the enzyme
  complex.
source_documents:
- genes/NEUCR/NCU01245/NCU01245-protnlm-source.json
- genes/NEUCR/NCU01245/NCU01245-uniprot.txt
- genes/NEUCR/NCU01245/NCU01245-ai-review.yaml
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-09
  source_reference_id: file:NEUCR/NCU01245/NCU01245-protnlm-source.json
  predicted_term:
    id: GO:0006383
    label: transcription by RNA polymerase III
  predicted_term_type: GO_BP
  review:
    assessment: LSP
    confidence_score: 2
    summary: The RPC4-specific domain identifies the C53 subunit of nuclear RNA polymerase III. Reconstitution
      of characterized yeast polymerase establishes transcriptional termination and recycling roles. GOA
      already includes tRNA transcription by RNA polymerase III (GO:0042797), so the emitted general polymerase
      III process is supported but less precise. This is conserved complex participation rather than autonomous
      polymerase catalysis.
    supported_by:
    - reference_id: PMID:16362040
      supporting_text: 'The specific requirement for

        the C37-C53 complex in terminator recognition was determined.'
    - reference_id: PMID:19940126
      supporting_text: 'Protein-RNA and protein-DNA photochemical cross-linking analysis places

        a segment of C53 close to the RNA 3'' end and transcribed DNA strand at the

        catalytic center of the pol III elongation complex.'
    - reference_id: file:NEUCR/NCU01245/NCU01245-uniprot.txt
      supporting_text: DR   InterPro; IPR007811; RPC4.
references:
- id: PMID:16362040
  title: A subcomplex of RNA polymerase III subunits involved in transcription termination and reinitiation.
  full_text_unavailable: false
- id: PMID:19940126
  title: The C53/C37 subcomplex of RNA polymerase III lies near the active site and participates in promoter
    opening.
  full_text_unavailable: true
- id: file:NEUCR/NCU01245/NCU01245-uniprot.txt
  title: 'UniProt record for NCU01245: domain and family evidence'
- id: file:NEUCR/NCU01245/NCU01245-protnlm-source.json
  title: Frozen live ProtNLM2 API response for NCU01245