ID   Q7RWZ3_NEUCR            Unreviewed;       844 AA.
AC   Q7RWZ3;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 3.
DT   10-JUN-2026, entry version 101.
DE   SubName: Full=SPX domain-containing protein {ECO:0000313|EMBL:EAA27007.3};
GN   ORFNames=NCU01540 {ECO:0000313|EMBL:EAA27007.3};
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA27007.3, ECO:0000313|Proteomes:UP000001805};
RN   [1] {ECO:0000313|EMBL:EAA27007.3, ECO:0000313|Proteomes:UP000001805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC   {ECO:0000313|Proteomes:UP000001805};
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA   FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA   Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA   Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA   Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA   Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA   Lander E.S., Nusbaum C., Birren B.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; CM002237; EAA27007.3; -; Genomic_DNA.
DR   RefSeq; XP_956243.3; XM_951150.3.
DR   AlphaFoldDB; Q7RWZ3; -.
DR   SMR; Q7RWZ3; -.
DR   FunCoup; Q7RWZ3; 84.
DR   STRING; 367110.Q7RWZ3; -.
DR   PaxDb; 367110-Q7RWZ3; -.
DR   GeneID; 3872403; -.
DR   KEGG; ncr:NCU01540; -.
DR   VEuPathDB; FungiDB:NCU01540; -.
DR   HOGENOM; CLU_005170_8_0_1; -.
DR   InParanoid; Q7RWZ3; -.
DR   OrthoDB; 6500128at2759; -.
DR   Proteomes; UP000001805; Chromosome 6, Linkage Group II.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005315; F:phosphate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006817; P:phosphate ion transport; IBA:GO_Central.
DR   GO; GO:0006797; P:polyphosphate metabolic process; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   CDD; cd01115; SLC13_permease; 1.
DR   CDD; cd14478; SPX_PHO87_PHO90_like; 1.
DR   InterPro; IPR004680; Cit_transptr-like_dom.
DR   InterPro; IPR004331; SPX_dom.
DR   PANTHER; PTHR10283:SF92; LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91; 1.
DR   PANTHER; PTHR10283; SOLUTE CARRIER FAMILY 13 MEMBER; 1.
DR   Pfam; PF03600; CitMHS; 1.
DR   Pfam; PF03105; SPX; 2.
DR   PROSITE; PS51382; SPX; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        376..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        410..443
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        463..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        510..537
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        553..572
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        592..615
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        635..654
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        661..682
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        688..707
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        728..761
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        773..795
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        816..839
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..260
FT                   /note="SPX"
FT                   /evidence="ECO:0000259|PROSITE:PS51382"
FT   REGION          93..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..153
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        154..166
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   844 AA;  93417 MW;  10832E4B848EDBB7 CRC64;
     MKFSHSIQFN AVPDWSTHYI AYSNLKKLIY QLEKVIHLSS GGDGESRPLI QHEDPEIVFV
     RALDVELEKV LSFYTVKERE LFEEVQNVLR DVDAFDEQSG DTDQERQLRP PTRGSEQQRP
     LRARSESLPS RASTDEGSNS DQSDNENTGL NTRGKQRRLS PGRRKSSTVI PGHMMSSIGD
     MTASTEMTRS RRFSTTFDDD YAEQAVLFSS GIMLKKRIIN LYVQLCELKS YIQLNRTGFS
     KVLKKFDKII DRQLRSKYMD TFVDTAYAFR PETTKTLEEQ IHLMVHAYMD IVTQGDEAAA
     TRDLRSHLRE HVVWERNTVW RELIGMERRA EAASLGHTLL GRDTDPTSHR LQGDDELMLP
     TKEIATPLGR FRLPAWLVSS TLMTLVIIFA IFFALLFIPI MKKPEQQNCL ALLVFVSLLW
     ATEAIPLFVT SLTIPFLCVV LRVFRDADKP HHRLGAKATT DAVFSAMWTP VIMLLLGGFT
     LAAALSKCGI DKRIATFVLS KAGTQPRTVL IANMAVAAFA SMLISNVAAP VLCFGIIEPM
     LRNLPAGSNM SKAVIMGIAL ASNVGGMLSP IASPQNIVAI GLMEPPPTWG EWFFIVIPVG
     VISLLLIWVL LLLTFQPGKG TSIVPIRPVK DRFTGVQWFV TLVTVATIGL WCASHQLEAE
     FGHMGVIAII PIVLFFGVGI LTKEDFNNFP WTIIILAAGG LALGKAVNSS GLLHTVTRLI
     TEDVQDFSLY GVLIVFSSLI LVIATFISHT VAALIILPLV YDVGKGLDEP HPNLLVMAGV
     LMCSAAMALP TSGFPNMTAI MKEDPAGQRY LQVKHFISRG VPSSLLTLLV TVTVGYAAMR
     VVGM
//