ID Q7SGY4_NEUCR Unreviewed; 314 AA. AC Q7SGY4; DT 15-DEC-2003, integrated into UniProtKB/TrEMBL. DT 15-DEC-2003, sequence version 1. DT 02-SEP-2026, entry version 100. DE RecName: Full=Transcriptional activator HAP2 {ECO:0000256|RuleBase:RU367155}; GN ORFNames=NCU03033 {ECO:0000313|EMBL:EAA36183.1}; OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / OS FGSC 987). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora. OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA36183.1, ECO:0000313|Proteomes:UP000001805}; RN [1] {ECO:0000313|EMBL:EAA36183.1, ECO:0000313|Proteomes:UP000001805} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987 RC {ECO:0000313|Proteomes:UP000001805}; RX PubMed=12712197; DOI=10.1038/nature01554; RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D., RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T., RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D., RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D., RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D., RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A., RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O., RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., RA Lander E.S., Nusbaum C., Birren B.; RT "The genome sequence of the filamentous fungus Neurospora crassa."; RL Nature 422:859-868(2003). CC -!- FUNCTION: Component of the sequence-specific heterotrimeric CC transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' CC box motif found in the promoters of its target genes. CC {ECO:0000256|RuleBase:RU367155}. CC -!- SUBUNIT: Heterotrimer. {ECO:0000256|RuleBase:RU367155}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, CC ECO:0000256|PROSITE-ProRule:PRU00966, ECO:0000256|RuleBase:RU367155}. CC -!- SIMILARITY: Belongs to the NFYA/HAP2 subunit family. CC {ECO:0000256|PROSITE-ProRule:PRU00966, ECO:0000256|RuleBase:RU367155}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CM002236; EAA36183.1; -; Genomic_DNA. DR RefSeq; XP_965419.1; XM_960326.2. DR AlphaFoldDB; Q7SGY4; -. DR SMR; Q7SGY4; -. DR FunCoup; Q7SGY4; 1011. DR STRING; 367110.Q7SGY4; -. DR PaxDb; 367110-Q7SGY4; -. DR GeneID; 3881569; -. DR KEGG; ncr:NCU03033; -. DR VEuPathDB; FungiDB:NCU03033; -. DR HOGENOM; CLU_045001_1_0_1; -. DR InParanoid; Q7SGY4; -. DR OMA; MGSQVQM; -. DR OrthoDB; 1097733at2759; -. DR Proteomes; UP000001805; Chromosome 1, Linkage Group I. DR GO; GO:0016602; C:CCAAT-binding factor complex; IBA:GO_Central. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR Gene3D; 6.10.250.2430; -; 1. DR InterPro; IPR001289; NFYA. DR PANTHER; PTHR12632; TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED; 1. DR Pfam; PF02045; CBFB_NFYA; 1. DR PRINTS; PR00616; CCAATSUBUNTB. DR SMART; SM00521; CBF; 1. DR PROSITE; PS51152; NFYA_HAP2_2; 1. PE 3: Inferred from homology; KW Activator {ECO:0000256|PROSITE-ProRule:PRU00966}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE- KW ProRule:PRU00966}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE- KW ProRule:PRU00966}; Reference proteome {ECO:0000313|Proteomes:UP000001805}; KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|PROSITE- KW ProRule:PRU00966}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, KW ECO:0000256|PROSITE-ProRule:PRU00966}. FT DNA_BIND 225..250 FT /note="NFYA/HAP2-type" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00966" FT REGION 1..63 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 100..145 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 164..185 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 216..314 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOTIF 194..217 FT /note="Subunit association domain (SAD)" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00966" FT COMPBIAS 8..63 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 106..117 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 130..145 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 165..180 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 255..269 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 270..284 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 314 AA; 33901 MW; A46287783BCFE26D CRC64; MMEYAQYQPA QNSHSNPHMQ TAYSSSAGGN SITSPSSQHL PQTSPILQTQ QHQPSPTQGH SMYQTQYGVP QQNMHYGMPL QAAALAATAA ASGTNYPNPY MAADPNLQQS PRMSGVNSKK DVRAGPRSPP QMNSIPPGQR RLSQVASPGV PNAQAMLNHA SRSAVPPPMT AAQQMPPPQS PEMASGAVEE SPLYVNAKQF HRILKRRVAR QKLEEQLRLT NKGRKPYLHE SRHNHAMRRP RGPGGRFLTA DEVAQMERDK VNGDVKQDGS EQSSVTAGSK TTGGTKRKAE STSGAPNKKA KAAPESPEDD DASD //