id: Q7S3B9
gene_symbol: NCU04637
taxon:
  id: NCBITaxon:367110
  label: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
status: COMPLETE
description: The emitted broad GO predictions are supported but less precise than existing defensible
  annotations.
source_documents:
- genes/NEUCR/NCU04637/NCU04637-protnlm-source.json
- genes/NEUCR/NCU04637/NCU04637-uniprot.txt
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-09
  source_reference_id: file:NEUCR/NCU04637/NCU04637-protnlm-source.json
  predicted_term:
    id: GO:0005737
    label: cytoplasm
  predicted_term_type: GO_CC
  review:
    assessment: LSP
    confidence_score: 2
    summary: PANTHER assigns the target to the Rvs167 subfamily, and its BAR-plus-SH3 architecture matches
      the characterized fungal endocytic adaptor. Rvs proteins bind membranes and act at cortical actin
      patches, supporting cytoplasmic residence. Cytoplasm is broader than the supported cortical actin
      patch annotation already present in GOA. The exact medial-cortex distribution used as a hydration
      source remains unresolved, but is not needed to establish the broader compartment.
    supported_by:
    - reference_id: file:NEUCR/NCU04637/NCU04637-uniprot.txt
      supporting_text: DR   PANTHER; PTHR47174:SF1; REDUCED VIABILITY UPON STARVATION PROTEIN 167; 1.
    - reference_id: PMID:20610658
      supporting_text: We show that the purified Rvs161-Rvs167 complex binds to liposomes in a curvature-independent
        manner and promotes tubule formation in vitro.
    - reference_id: PMID:20610658
      supporting_text: Rvs161 consists solely of a BAR domain, whereas Rvs167 is composed of a BAR domain
        followed by a region rich in glycine, proline, and alanine (GPA), and an SH3 (Src-homology 3)
        domain at its C-terminus
    - reference_id: file:NEUCR/NCU04637/NCU04637-uniprot.txt
      supporting_text: DR   GO; GO:0030479; C:actin cortical patch; IBA:GO_Central.
references:
- id: file:NEUCR/NCU04637/NCU04637-uniprot.txt
  title: NCU04637-uniprot.txt
  findings: []
- id: PMID:20610658
  title: Dissecting BAR domain function in the yeast Amphiphysins Rvs161 and Rvs167 during endocytosis.
  findings: []
  full_text_unavailable: false