NCU04937

UniProt ID: Q7S3T0
Organism: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Review Status: COMPLETE
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Gene Description

NCU04937 encodes a predicted 114-residue protein dominated by a glutamine-rich region. The current sequence carries a predicted coiled-coil segment but no assigned DNA-binding domain. Its molecular function and subcellular localization are uncharacterized.

References

file:NEUCR/NCU04937/NCU04937-uniprot.txt
NCU04937-uniprot.txt

External Prediction Reviews

These computational predictions are reviewed separately from the GOA annotation set used for this review. The assessments below are from this project and do not constitute official GO annotations or endorsement by GO/UniProt. They are not included in the existing annotation review above.

ProtNLM2 External predictions

View prediction review YAML · NCU04937-protnlm-predictions-review.yaml · Review status: COMPLETE

DNA-binding function remains uncertain for this short glutamine-rich protein.

Source documents: genes/NEUCR/NCU04937/NCU04937-protnlm-source.json · genes/NEUCR/NCU04937/NCU04937-uniprot.txt

Review score: 2 = concordant with evidence; 1 = uncertain; 0 = discordant with evidence. This is an assessment score, not a model probability.

GO:0003677 DNA binding GO_MF
UNC — Uncertain Review score: 1/2
Prediction method: ProtNLM2 · Version: UniProt API snapshot 2026-09-09 · file:NEUCR/NCU04937/NCU04937-protnlm-source.json
Review rationale: The current 114-residue protein is glutamine-rich and has a predicted coiled-coil region, with no diagnostic DNA-binding domain assigned. The prediction cites human THAP11 (Q96EK4; phmmer score 29.1), but shared low-complexity or coiled-coil content does not establish the donor’s DNA-binding function in this target. No target-specific binding assay or defensible DNA-binding subfamily placement was recovered. DNA binding cannot presently be validated or refuted.
Supporting Evidence:

Deep Research

Manual

(NCU04937-deep-research-manual.md)

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📚 Additional Documentation

Notes

(NCU04937-notes.md)

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Protnlm Location Review

(NCU04937-protnlm-location-review.md)

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📄 View Raw YAML

 
id: Q7S3T0
gene_symbol: NCU04937
product_type: PROTEIN
status: COMPLETE
taxon:
  id: NCBITaxon:367110
  label: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
description: NCU04937 encodes a predicted 114-residue protein dominated by a glutamine-rich region. The
  current sequence carries a predicted coiled-coil segment but no assigned DNA-binding domain. Its molecular
  function and subcellular localization are uncharacterized.
core_functions: []
references:
- id: file:NEUCR/NCU04937/NCU04937-uniprot.txt
  title: NCU04937-uniprot.txt
  findings: []