ID   Q7S2F2_NEUCR            Unreviewed;       584 AA.
AC   Q7S2F2;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 3.
DT   02-SEP-2026, entry version 115.
DE   RecName: Full=glycerol kinase {ECO:0000256|ARBA:ARBA00012099};
DE            EC=2.7.1.30 {ECO:0000256|ARBA:ARBA00012099};
DE   AltName: Full=ATP:glycerol 3-phosphotransferase {ECO:0000256|ARBA:ARBA00043149};
GN   ORFNames=NCU06005 {ECO:0000313|EMBL:EAA29577.3};
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA29577.3, ECO:0000313|Proteomes:UP000001805};
RN   [1] {ECO:0000313|EMBL:EAA29577.3, ECO:0000313|Proteomes:UP000001805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC   {ECO:0000313|Proteomes:UP000001805};
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA   FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA   Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA   Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA   Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA   Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA   Lander E.S., Nusbaum C., Birren B.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase
CC       pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00005190}.
CC   -!- SIMILARITY: Belongs to the FGGY kinase family.
CC       {ECO:0000256|ARBA:ARBA00009156, ECO:0000256|RuleBase:RU003733}.
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DR   EMBL; CM002241; EAA29577.3; -; Genomic_DNA.
DR   RefSeq; XP_958813.3; XM_953720.3.
DR   AlphaFoldDB; Q7S2F2; -.
DR   SMR; Q7S2F2; -.
DR   FunCoup; Q7S2F2; 333.
DR   STRING; 367110.Q7S2F2; -.
DR   PaxDb; 367110-Q7S2F2; -.
DR   GeneID; 3874960; -.
DR   KEGG; ncr:NCU06005; -.
DR   VEuPathDB; FungiDB:NCU06005; -.
DR   HOGENOM; CLU_009281_2_2_1; -.
DR   InParanoid; Q7S2F2; -.
DR   OrthoDB; 5422795at2759; -.
DR   UniPathway; UPA00618; UER00672.
DR   Proteomes; UP000001805; Chromosome 5, Linkage Group VI.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0004370; F:glycerol kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0046167; P:glycerol-3-phosphate biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006641; P:triglyceride metabolic process; IBA:GO_Central.
DR   CDD; cd07792; ASKHA_NBD_FGGY_GK1-3-like; 1.
DR   FunFam; 3.30.420.40:FF:000086; Glycerol kinase; 1.
DR   FunFam; 3.30.420.40:FF:000085; Glycerol kinase 2; 1.
DR   Gene3D; 3.30.420.40; -; 2.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000577; Carb_kinase_FGGY.
DR   InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR   InterPro; IPR018485; FGGY_C.
DR   InterPro; IPR018484; FGGY_N.
DR   InterPro; IPR042018; GK1-3_metazoan-type.
DR   InterPro; IPR005999; Glycerol_kin.
DR   NCBIfam; TIGR01311; glycerol_kin; 1.
DR   NCBIfam; NF000756; PRK00047.1; 1.
DR   PANTHER; PTHR10196:SF69; GLYCEROL KINASE; 1.
DR   PANTHER; PTHR10196; SUGAR KINASE; 1.
DR   Pfam; PF02782; FGGY_C; 1.
DR   Pfam; PF00370; FGGY_N; 1.
DR   PIRSF; PIRSF000538; GlpK; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   PROSITE; PS00933; FGGY_KINASES_1; 1.
DR   PROSITE; PS00445; FGGY_KINASES_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Glycerol metabolism {ECO:0000256|ARBA:ARBA00022798};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU003733};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003733}.
FT   DOMAIN          64..319
FT                   /note="Carbohydrate kinase FGGY N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00370"
FT   DOMAIN          329..519
FT                   /note="Carbohydrate kinase FGGY C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02782"
SQ   SEQUENCE   584 AA;  63798 MW;  1CABCAD4A80140C1 CRC64;
     MKLLNLNDGV EAGVMCVEPT LTNDGMDARN LAKAHKGPIV THLEHLPRGI HETPEERKNH
     WFVGSVDQGT TSSRFLIFNG EGDPVASHQI EFENLYPKSG WHEHDPMTLL NSVEECIEGA
     MRKFQRLGFS KNDIRSIGIT NQRETTLVWD HETGEPLYNA VVWSDTRTKS LVRDLKDKDG
     ADAIKDLCGL PLSTYPSSVK LLWLIENVEA VKQAYEEGRL AFGTVDTWLI YKLNGGAQAE
     SPVHVTDSTN ASRTMFMNIR TLQYDDKMLG FFGIDRTKVH LPKIVPSSDP ECFGRIASGA
     LSGVPIAGCL GDQSSALVGQ CGFNPGQAKN TYGTGCFLLY NVGTEPVISQ YGLLSTVAYD
     FGQGRAPVYA LEGSIAVAGA GVTFLQNNLN FIENAKQIND LAESVPDNGG VVFVTAFSGL
     FAPYWIDDAK GTLFGITQHT QKGHIARATL EATCFQTKAI LDAMEKDSGC KLKLLAVDGG
     LSNSDLTMQT QADISGIPVD RPAMCETTAL GAAIAAGLAT GVWSDTTELQ EVNRTGRKVF
     EPKISRKCAE KRFKKWNQAV QMSRGWLQDN DNEDDECDEE VKKA
//