id: V5IQW8
gene_symbol: NCU07379
taxon:
  id: NCBITaxon:367110
  label: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
status: COMPLETE
description: The emitted broad GO predictions are supported but less precise than existing defensible
  annotations.
source_documents:
- genes/NEUCR/NCU07379/NCU07379-protnlm-source.json
- genes/NEUCR/NCU07379/NCU07379-uniprot.txt
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-09
  source_reference_id: file:NEUCR/NCU07379/NCU07379-protnlm-source.json
  predicted_term:
    id: GO:0003700
    label: DNA-binding transcription factor activity
  predicted_term_type: GO_MF
  review:
    assessment: LSP
    confidence_score: 2
    summary: The target has a bZIP superfamily assignment and is placed specifically with fungal AP-1/Yap1-related
      transcription factors. Characterized yeast Yap1 is required for cis-element-dependent transcriptional
      activation, supporting a conserved DNA-binding regulator function. GOA already includes the more
      specific RNA polymerase II transcription activator activity by PAINT. The generic transcription-factor
      prediction is therefore less precise, without implying an established Neurospora stress response
      or target regulon.
    supported_by:
    - reference_id: file:NEUCR/NCU07379/NCU07379-uniprot.txt
      supporting_text: DR   PANTHER; PTHR40621:SF6; AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED; 1.
    - reference_id: PMID:2542125
      supporting_text: Disruption of the YAP1 gene demonstrates this gene is not essential but is required
        for AP-1 recognition element-dependent transcriptional activation.
    - reference_id: file:NEUCR/NCU07379/NCU07379-uniprot.txt
      supporting_text: DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase
        II-specific; IBA:GO_Central.
references:
- id: file:NEUCR/NCU07379/NCU07379-uniprot.txt
  title: NCU07379-uniprot.txt
  findings: []
- id: PMID:2542125
  title: Yeast YAP1 encodes a novel form of the jun family of transcriptional activator proteins.
  findings: []
  full_text_unavailable: true