id: Q7S234 gene_symbol: NCU09880 product_type: PROTEIN status: COMPLETE taxon: id: NCBITaxon:367110 label: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) description: NCU09880 is a canonical SmG protein that binds snRNA in the heptameric Sm ring. SmG-containing U1, U2, U4 and U5 small nuclear ribonucleoproteins assemble into the spliceosome and support pre-mRNA splicing. SmG also participates in the assembly intermediates that build these RNA-protein particles. existing_annotations: - term: &id001 id: GO:0000387 label: spliceosomal snRNP assembly evidence_type: IEA original_reference_id: GO_REF:0000104 qualifier: involved_in supporting_entities: - UniRule:UR000481797 review: summary: The SmG-specific domain identifies a canonical Sm-ring subunit. action: ACCEPT reason: The SmG-specific domain identifies a canonical Sm-ring subunit. Characterized yeast SmG participates in the U1, U2, U4 and U5 snRNP scaffolds, and mutational interactions establish its functional contribution to spliceosome assembly and pre-mRNA splicing. supported_by: - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' - reference_id: PMID:27417296 supporting_text: 'Tests of pairwise combinations of SmG, SmE, SmF, SmB, and SmD3 alleles highlighted the inherent redundancies within the Sm ring, whereby simultaneous mutations of the RNA binding sites of any two of the Sm subunits are lethal.' - term: id: GO:0000398 label: mRNA splicing, via spliceosome evidence_type: IBA original_reference_id: GO_REF:0000033 qualifier: involved_in supporting_entities: - PANTHER:PTN000058285 - PomBase:SPBC4B4.05 - SGD:S000002965 - UniProtKB:P62308 - UniProtKB:Q382A6 review: summary: The SmG-specific domain identifies a canonical Sm-ring subunit. action: ACCEPT reason: The SmG-specific domain identifies a canonical Sm-ring subunit. Characterized yeast SmG participates in the U1, U2, U4 and U5 snRNP scaffolds, and mutational interactions establish its functional contribution to spliceosome assembly and pre-mRNA splicing. supported_by: - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' - reference_id: PMID:27417296 supporting_text: 'Tests of pairwise combinations of SmG, SmE, SmF, SmB, and SmD3 alleles highlighted the inherent redundancies within the Sm ring, whereby simultaneous mutations of the RNA binding sites of any two of the Sm subunits are lethal.' - term: &id002 id: GO:0000398 label: mRNA splicing, via spliceosome evidence_type: IEA original_reference_id: GO_REF:0000120 qualifier: involved_in supporting_entities: - UniProtKB:P40204 - sgd:YFL017W-A - InterPro:IPR034098 - UniRule:UR000481797 review: summary: The SmG-specific domain identifies a canonical Sm-ring subunit. action: ACCEPT reason: The SmG-specific domain identifies a canonical Sm-ring subunit. Characterized yeast SmG participates in the U1, U2, U4 and U5 snRNP scaffolds, and mutational interactions establish its functional contribution to spliceosome assembly and pre-mRNA splicing. supported_by: - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' - reference_id: PMID:27417296 supporting_text: 'Tests of pairwise combinations of SmG, SmE, SmF, SmB, and SmD3 alleles highlighted the inherent redundancies within the Sm ring, whereby simultaneous mutations of the RNA binding sites of any two of the Sm subunits are lethal.' - term: id: GO:0003723 label: RNA binding evidence_type: IBA original_reference_id: GO_REF:0000033 qualifier: contributes_to supporting_entities: - PANTHER:PTN000058283 - SGD:S000005091 review: summary: Canonical SmG contacts the snRNA Sm site within the heptameric ring. action: ACCEPT reason: Canonical SmG contacts the snRNA Sm site within the heptameric ring. Conserved RNA-contact mutagenesis in yeast supports RNA binding by the subunit in its normal complex context. supported_by: - reference_id: PMID:27417296 supporting_text: 'Tests of pairwise combinations of SmG, SmE, SmF, SmB, and SmD3 alleles highlighted the inherent redundancies within the Sm ring, whereby simultaneous mutations of the RNA binding sites of any two of the Sm subunits are lethal.' - term: &id003 id: GO:0003723 label: RNA binding evidence_type: IEA original_reference_id: GO_REF:0000120 qualifier: enables supporting_entities: - InterPro:IPR047575 - UniRule:UR000481797 - UniRule:UR001714480 review: summary: Canonical SmG contacts the snRNA Sm site within the heptameric ring. action: ACCEPT reason: Canonical SmG contacts the snRNA Sm site within the heptameric ring. Conserved RNA-contact mutagenesis in yeast supports RNA binding by the subunit in its normal complex context. supported_by: - reference_id: PMID:27417296 supporting_text: 'Tests of pairwise combinations of SmG, SmE, SmF, SmB, and SmD3 alleles highlighted the inherent redundancies within the Sm ring, whereby simultaneous mutations of the RNA binding sites of any two of the Sm subunits are lethal.' - term: &id005 id: GO:0005634 label: nucleus evidence_type: IEA original_reference_id: GO_REF:0000044 qualifier: located_in supporting_entities: - UniProtKB-SubCell:SL-0191 review: summary: SmG-containing snRNPs function in nuclear pre-mRNA splicing. action: ACCEPT reason: SmG-containing snRNPs function in nuclear pre-mRNA splicing. The conserved SmG identity and characterized nuclear snRNP membership support nuclear localization; cytoplasmic assembly intermediates are compatible with this annotation. supported_by: - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' - term: &id004 id: GO:0005681 label: spliceosomal complex evidence_type: IEA original_reference_id: GO_REF:0000002 qualifier: part_of supporting_entities: - InterPro:IPR034098 review: summary: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. action: ACCEPT reason: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. Canonical Sm rings scaffold U1, U2, U4 and U5 snRNPs and persist with their snRNAs through the relevant spliceosome intermediates, supporting these conserved memberships and the curator-established phylogenetic assignments. supported_by: - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' - term: id: GO:0005682 label: U5 snRNP evidence_type: IBA original_reference_id: GO_REF:0000033 qualifier: part_of supporting_entities: - PANTHER:PTN000058285 - PomBase:SPBC4B4.05 - SGD:S000002965 review: summary: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. action: ACCEPT reason: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. Canonical Sm rings scaffold U1, U2, U4 and U5 snRNPs and persist with their snRNAs through the relevant spliceosome intermediates, supporting these conserved memberships and the curator-established phylogenetic assignments. supported_by: - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' - term: id: GO:0005682 label: U5 snRNP evidence_type: IEA original_reference_id: GO_REF:0000120 qualifier: part_of supporting_entities: - UniProtKB:O74966 - PomBase:SPBC4B4.05.1:pep - UniProtKB:P40204 - sgd:YFL017W-A review: summary: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. action: ACCEPT reason: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. Canonical Sm rings scaffold U1, U2, U4 and U5 snRNPs and persist with their snRNAs through the relevant spliceosome intermediates, supporting these conserved memberships and the curator-established phylogenetic assignments. supported_by: - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' - term: id: GO:0005685 label: U1 snRNP evidence_type: IBA original_reference_id: GO_REF:0000033 qualifier: part_of supporting_entities: - PANTHER:PTN000058285 - PomBase:SPBC4B4.05 - RGD:9286705 - SGD:S000002965 - UniProtKB:P62308 review: summary: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. action: ACCEPT reason: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. Canonical Sm rings scaffold U1, U2, U4 and U5 snRNPs and persist with their snRNAs through the relevant spliceosome intermediates, supporting these conserved memberships and the curator-established phylogenetic assignments. supported_by: - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' - term: id: GO:0005685 label: U1 snRNP evidence_type: IEA original_reference_id: GO_REF:0000120 qualifier: part_of supporting_entities: - UniProtKB:O74966 - PomBase:SPBC4B4.05.1:pep - UniProtKB:P40204 - sgd:YFL017W-A review: summary: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. action: ACCEPT reason: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. Canonical Sm rings scaffold U1, U2, U4 and U5 snRNPs and persist with their snRNAs through the relevant spliceosome intermediates, supporting these conserved memberships and the curator-established phylogenetic assignments. supported_by: - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' - term: id: GO:0005686 label: U2 snRNP evidence_type: IBA original_reference_id: GO_REF:0000033 qualifier: part_of supporting_entities: - PANTHER:PTN000058285 - PomBase:SPBC4B4.05 review: summary: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. action: ACCEPT reason: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. Canonical Sm rings scaffold U1, U2, U4 and U5 snRNPs and persist with their snRNAs through the relevant spliceosome intermediates, supporting these conserved memberships and the curator-established phylogenetic assignments. supported_by: - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' - term: id: GO:0005686 label: U2 snRNP evidence_type: IEA original_reference_id: GO_REF:0000107 qualifier: part_of supporting_entities: - UniProtKB:O74966 - PomBase:SPBC4B4.05.1:pep review: summary: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. action: ACCEPT reason: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. Canonical Sm rings scaffold U1, U2, U4 and U5 snRNPs and persist with their snRNAs through the relevant spliceosome intermediates, supporting these conserved memberships and the curator-established phylogenetic assignments. supported_by: - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' - term: id: GO:0005687 label: U4 snRNP evidence_type: IBA original_reference_id: GO_REF:0000033 qualifier: part_of supporting_entities: - PANTHER:PTN000058285 - SGD:S000002965 - UniProtKB:P62308 review: summary: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. action: ACCEPT reason: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. Canonical Sm rings scaffold U1, U2, U4 and U5 snRNPs and persist with their snRNAs through the relevant spliceosome intermediates, supporting these conserved memberships and the curator-established phylogenetic assignments. supported_by: - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' - term: id: GO:0005687 label: U4 snRNP evidence_type: IEA original_reference_id: GO_REF:0000107 qualifier: part_of supporting_entities: - UniProtKB:P40204 - sgd:YFL017W-A review: summary: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. action: ACCEPT reason: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. Canonical Sm rings scaffold U1, U2, U4 and U5 snRNPs and persist with their snRNAs through the relevant spliceosome intermediates, supporting these conserved memberships and the curator-established phylogenetic assignments. supported_by: - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' - term: id: GO:0032991 label: protein-containing complex evidence_type: IEA original_reference_id: GO_REF:0000117 qualifier: part_of supporting_entities: - ARBA:ARBA00028902 review: summary: Protein-containing complex is correct but uninformative for a canonical SmG subunit. action: MODIFY reason: Protein-containing complex is correct but uninformative for a canonical SmG subunit. Its supported role is in spliceosomal snRNPs and spliceosome complexes. supported_by: - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' proposed_replacement_terms: - id: GO:0005681 label: spliceosomal complex - term: id: GO:0034719 label: SMN-Sm protein complex evidence_type: IBA original_reference_id: GO_REF:0000033 qualifier: part_of supporting_entities: - PANTHER:PTN000058285 - UniProtKB:P62308 review: summary: SmG is a substrate subunit in the SMN-mediated Sm assembly intermediate. action: ACCEPT reason: SmG is a substrate subunit in the SMN-mediated Sm assembly intermediate. The human structure explicitly contains SmG in the SmD1/D2/F/E/G pentamer bound to Gemin2 and SMN. The curated ancestral assertion transfers this conserved assembly interaction, not a stable catalytic-spliceosome SMN membership. supported_by: - reference_id: PMID:21816274 supporting_text: 'Here, we describe the 2.5 Å crystal structure of Gemin2 bound to SmD1/D2/F/E/G pentamer and SMN''s Gemin2-binding domain, a key assembly intermediate.' - term: id: GO:0036261 label: 7-methylguanosine cap hypermethylation evidence_type: IEA original_reference_id: GO_REF:0000107 qualifier: involved_in supporting_entities: - UniProtKB:P40204 - sgd:YFL017W-A review: summary: Cap hypermethylation is catalyzed by Tgs1 and is coupled to snRNP biogenesis, so a noncatalytic SmG contribution is plausible. action: UNDECIDED reason: Cap hypermethylation is catalyzed by Tgs1 and is coupled to snRNP biogenesis, so a noncatalytic SmG contribution is plausible. The retrieved experiments establish SmG-dependent ring assembly but do not resolve the specific SmG requirement for cap hypermethylation underlying this yeast-to-Neurospora transfer. This is not rejected merely because SmG lacks methyltransferase activity. supported_by: - reference_id: PMID:11983179 supporting_text: 'Here, we show that yeast Tgs1p, an evolutionarily conserved protein carrying a signature of S-AdoMet methyltransferase, is essential for hypermethylation of the m(7)G caps of both snRNAs and snoRNAs.' - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' - term: id: GO:0046540 label: U4/U6 x U5 tri-snRNP complex evidence_type: IEA original_reference_id: GO_REF:0000107 qualifier: part_of supporting_entities: - UniProtKB:P40204 - sgd:YFL017W-A review: summary: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. action: ACCEPT reason: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. Canonical Sm rings scaffold U1, U2, U4 and U5 snRNPs and persist with their snRNAs through the relevant spliceosome intermediates, supporting these conserved memberships and the curator-established phylogenetic assignments. supported_by: - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' - term: id: GO:0071004 label: U2-type prespliceosome evidence_type: IBA original_reference_id: GO_REF:0000033 qualifier: part_of supporting_entities: - PANTHER:PTN000058284 - SGD:S000002965 review: summary: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. action: ACCEPT reason: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. Canonical Sm rings scaffold U1, U2, U4 and U5 snRNPs and persist with their snRNAs through the relevant spliceosome intermediates, supporting these conserved memberships and the curator-established phylogenetic assignments. supported_by: - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' - term: id: GO:0071004 label: U2-type prespliceosome evidence_type: IEA original_reference_id: GO_REF:0000107 qualifier: part_of supporting_entities: - UniProtKB:P40204 - sgd:YFL017W-A review: summary: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. action: ACCEPT reason: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. Canonical Sm rings scaffold U1, U2, U4 and U5 snRNPs and persist with their snRNAs through the relevant spliceosome intermediates, supporting these conserved memberships and the curator-established phylogenetic assignments. supported_by: - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' - term: id: GO:0071011 label: precatalytic spliceosome evidence_type: IBA original_reference_id: GO_REF:0000033 qualifier: part_of supporting_entities: - PANTHER:PTN000058285 - UniProtKB:P62308 review: summary: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. action: ACCEPT reason: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. Canonical Sm rings scaffold U1, U2, U4 and U5 snRNPs and persist with their snRNAs through the relevant spliceosome intermediates, supporting these conserved memberships and the curator-established phylogenetic assignments. supported_by: - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' - term: id: GO:0071013 label: catalytic step 2 spliceosome evidence_type: IBA original_reference_id: GO_REF:0000033 qualifier: part_of supporting_entities: - PANTHER:PTN000058284 - UniProtKB:P62308 review: summary: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. action: ACCEPT reason: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. Canonical Sm rings scaffold U1, U2, U4 and U5 snRNPs and persist with their snRNAs through the relevant spliceosome intermediates, supporting these conserved memberships and the curator-established phylogenetic assignments. supported_by: - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' - term: id: GO:0071014 label: post-mRNA release spliceosomal complex evidence_type: IEA original_reference_id: GO_REF:0000107 qualifier: part_of supporting_entities: - UniProtKB:O74966 - PomBase:SPBC4B4.05.1:pep review: summary: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. action: ACCEPT reason: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. Canonical Sm rings scaffold U1, U2, U4 and U5 snRNPs and persist with their snRNAs through the relevant spliceosome intermediates, supporting these conserved memberships and the curator-established phylogenetic assignments. supported_by: - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' - term: id: GO:0097526 label: spliceosomal tri-snRNP complex evidence_type: IBA original_reference_id: GO_REF:0000033 qualifier: part_of supporting_entities: - PANTHER:PTN000058285 - SGD:S000002965 - UniProtKB:P62308 review: summary: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. action: ACCEPT reason: The SmG-specific subfamily distinguishes this protein from the related Lsm7 paralog. Canonical Sm rings scaffold U1, U2, U4 and U5 snRNPs and persist with their snRNAs through the relevant spliceosome intermediates, supporting these conserved memberships and the curator-established phylogenetic assignments. supported_by: - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' references: - id: GO_REF:0000002 title: Gene Ontology annotation through association of InterPro records with GO terms findings: [] - id: GO_REF:0000033 title: Annotation inferences using phylogenetic trees findings: [] - id: GO_REF:0000044 title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt findings: [] - id: GO_REF:0000104 title: Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features findings: [] - id: GO_REF:0000107 title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara findings: [] - id: GO_REF:0000117 title: Electronic Gene Ontology annotations created by ARBA machine learning models findings: [] - id: GO_REF:0000120 title: Combined Automated Annotation using Multiple IEA Methods findings: [] - id: PMID:27417296 title: Structure-function analysis and genetic interactions of the SmG, SmE, and SmF subunits of the yeast Sm protein ring. full_text_unavailable: false - id: PMID:21816274 title: Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly. full_text_unavailable: true - id: PMID:11983179 title: Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus. full_text_unavailable: true - id: file:NEUCR/NCU09880/NCU09880-uniprot.txt title: 'UniProt record for NCU09880: domain and family evidence' core_functions: - description: NCU09880 is a canonical SmG protein that binds snRNA in the heptameric Sm ring. SmG-containing U1, U2, U4 and U5 small nuclear ribonucleoproteins assemble into the spliceosome and support pre-mRNA splicing. SmG also participates in the assembly intermediates that build these RNA-protein particles. supported_by: - reference_id: PMID:27417296 supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5 snRNPs that direct pre-mRNA splicing.' - reference_id: PMID:27417296 supporting_text: 'Tests of pairwise combinations of SmG, SmE, SmF, SmB, and SmD3 alleles highlighted the inherent redundancies within the Sm ring, whereby simultaneous mutations of the RNA binding sites of any two of the Sm subunits are lethal.' - reference_id: file:NEUCR/NCU09880/NCU09880-uniprot.txt supporting_text: DR InterPro; IPR034098; Sm_G. directly_involved_in: - *id001 - *id002 molecular_function: *id003 in_complex: *id004 locations: - *id005