id: Q7S234
gene_symbol: NCU09880
locus_tag: NCU09880
taxon:
  id: NCBITaxon:367110
  label: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
status: COMPLETE
description: NCU09880 is a canonical SmG protein that binds snRNA in the heptameric Sm ring. SmG-containing
  U1, U2, U4 and U5 small nuclear ribonucleoproteins assemble into the spliceosome and support pre-mRNA
  splicing. SmG also participates in the assembly intermediates that build these RNA-protein particles.
source_documents:
- genes/NEUCR/NCU09880/NCU09880-protnlm-source.json
- genes/NEUCR/NCU09880/NCU09880-uniprot.txt
- genes/NEUCR/NCU09880/NCU09880-ai-review.yaml
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-09
  source_reference_id: file:NEUCR/NCU09880/NCU09880-protnlm-source.json
  predicted_term:
    id: GO:0005681
    label: spliceosomal complex
  predicted_term_type: GO_CC
  review:
    assessment: LSP
    confidence_score: 2
    summary: The SmG-specific domain distinguishes this protein from Lsm paralogs. Characterized yeast
      SmG is part of the canonical RNA-binding ring in U1, U2, U4 and U5 snRNPs. Curator-reviewed GOA
      includes U2-type prespliceosome (GO:0071004), a cellular-component descendant of spliceosomal complex.
      The emitted complex term is supported but less precise than that established complex assignment.
    supported_by:
    - reference_id: PMID:27417296
      supporting_text: 'A seven-subunit Sm protein ring forms a core scaffold of the U1, U2, U4, and U5

        snRNPs that direct pre-mRNA splicing.'
    - reference_id: PMID:27417296
      supporting_text: 'Tests of pairwise combinations of

        SmG, SmE, SmF, SmB, and SmD3 alleles highlighted the inherent redundancies

        within the Sm ring, whereby simultaneous mutations of the RNA binding sites of

        any two of the Sm subunits are lethal.'
    - reference_id: file:NEUCR/NCU09880/NCU09880-uniprot.txt
      supporting_text: DR   InterPro; IPR034098; Sm_G.
references:
- &id001
  id: PMID:27417296
  title: Structure-function analysis and genetic interactions of the SmG, SmE, and SmF subunits of the
    yeast Sm protein ring.
  full_text_unavailable: false
- *id001
- id: file:NEUCR/NCU09880/NCU09880-uniprot.txt
  title: 'UniProt record for NCU09880: domain and family evidence'
- id: file:NEUCR/NCU09880/NCU09880-protnlm-source.json
  title: Frozen live ProtNLM2 API response for NCU09880