ID   A7UX10_NEUCR            Unreviewed;       541 AA.
AC   A7UX10;
DT   23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   23-OCT-2007, sequence version 1.
DT   02-SEP-2026, entry version 76.
DE   SubName: Full=DUF890 domain-containing protein {ECO:0000313|EMBL:EDO65037.1};
GN   ORFNames=NCU11362 {ECO:0000313|EMBL:EDO65037.1};
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110 {ECO:0000313|EMBL:EDO65037.1, ECO:0000313|Proteomes:UP000001805};
RN   [1] {ECO:0000313|EMBL:EDO65037.1, ECO:0000313|Proteomes:UP000001805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC   {ECO:0000313|Proteomes:UP000001805};
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA   FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA   Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA   Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA   Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA   Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA   Lander E.S., Nusbaum C., Birren B.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM002239; EDO65037.1; -; Genomic_DNA.
DR   RefSeq; XP_001728128.1; XM_001728076.2.
DR   AlphaFoldDB; A7UX10; -.
DR   SMR; A7UX10; -.
DR   STRING; 367110.A7UX10; -.
DR   PaxDb; 367110-A7UX10; -.
DR   GeneID; 5847241; -.
DR   KEGG; ncr:NCU11362; -.
DR   VEuPathDB; FungiDB:NCU11362; -.
DR   HOGENOM; CLU_027534_0_1_1; -.
DR   InParanoid; A7UX10; -.
DR   OMA; EHKIDNY; -.
DR   OrthoDB; 514248at2759; -.
DR   Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR   GO; GO:0052907; F:23S rRNA (adenine(1618)-N(6))-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0070475; P:rRNA base methylation; IBA:GO_Central.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   FunFam; 3.40.50.150:FF:000616; DUF890 domain protein (AFU_orthologue AFUA_7G05590); 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR010286; METTL16/RlmF.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR13393:SF0; RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16; 1.
DR   PANTHER; PTHR13393; SAM-DEPENDENT METHYLTRANSFERASE; 1.
DR   Pfam; PF05971; Methyltransf_10; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   REGION          1..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          472..493
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..50
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   541 AA;  60558 MW;  54DFABB02DD0BF82 CRC64;
     METNKRKAAV EAGDEHNLAG EGELNSPVRE PEAKRQKQTN NEDIQGQPAQ EATKPIPESD
     RPHNIRSAPP SGPGTGLGQA VVATGRAPRK WTDEYFRNLY TKDPSFKYLG QKDPDFALFL
     DSKNQLDFND PAAVMQLTKT LLKIDYGLKI DLPPDRLCPP VPNRHNYILW LSSLLSSSSY
     HPHFSPSSNQ NNYSRPIIGL DIGTGASAIY PLLGCVQHPS WSFIATDIDA HSLSFAQRNI
     HLNNLQDRIT LLHRTPDQPL IPFDSRILTT RGIDKIDFTM CNPPFYSSPA DLLSSAAKKS
     RPPLTACTGA PVEMVCAGGE VAHIFKMIDE SLVLRGKVTW YTSMVGKVTS LETVVDRLRK
     ENINNYAVTE LVQGKQTKRW VVGWSFGGMR AGEAEGRGVG GVWKKLLPPV VRMEVGGWKE
     REKVEKLVER VKQTVEGLEL MSWDWSGERM RGVGRASGNV WSRTWRRKRE REMKAAEEGK
     KREDGDGNGT KEEEECKLGF EVVIEVGKDA ETKVVLLWRE GHDQGLFESL WGYLQGKLKD
     L
//