acon-3

Gene Description

acon-3 (aconidiate-3; 'Acr1', NCU07617) encodes a protein of the MEDUSA/MedA family of fungal conidiation regulators (PANTHER PTHR39463; DUF7082 domain), inferred by phylogenetic descent to act in the nucleus. It acts downstream of the fluffy (FL) master regulator and is required for later stages of macroconidiation: elevated FL expression does not bypass the acon-3 conidiation defect. Its precise molecular function is uncharacterized, and its position relative to the conidiation-specific con genes has not been established experimentally.

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0005634 nucleus	IBA GO_REF:0000033	ACCEPT	Summary: Accept: nuclear localization, consistent with a nuclear conidiation-stage regulator. Reason: Phylogenetic inference (IBA) from the MEDUSA/MedA family (PANTHER PTHR39463), whose characterized members are nuclear conidiation regulators. No direct localization evidence for ACON-3 itself is available, so the IBA stands on its own rather than on any primary citation.
GO:0048315 conidium formation	IMP PMID:15126394 The fluffy gene of Neurospora crassa is necessary and suffic...	NEW	Summary: Proposed new annotation. The acon-3 mutant is conidiation-defective, but GOA holds only the phylogenetically inferred nucleus term and no process term for the stage the gene is named for. Reason: The one experimentally established fact about acon-3 is a loss-of-function conidiation defect that elevated fl expression does not bypass, placing acon-3 downstream of the fl master regulator and making it required for later conidiation stages. acts_upstream_of_or_within is the correct qualifier - ACON-3's molecular activity is uncharacterized, so no more specific involvement can be asserted, and no claim is made here about its position relative to the con genes. Supporting Evidence: PMID:15126394 Two other genes, acon-2 and acon-3, play major roles in controlling development. PMID:15126394 Elevated expression of fl leads to induction of development of the acon-2 mutant in nitrogen-starved cultures, but does not bypass the conidiation defect of the acon-3 mutant.

Core Functions

Stage regulator of macroconidiation (MEDUSA/MedA family, DUF7082), inferred nuclear by phylogenetic descent: ACON-3 acts downstream of the fluffy master regulator and is required for later conidiation stages. Its molecular activity is uncharacterized, so no molecular_function is asserted.

Directly Involved In:

conidium formation

Cellular Locations:

nucleus

Supporting Evidence:

PMID:15126394
does not bypass the conidiation defect of the acon-3 mutant

Gene Description

Existing Annotations Review

Core Functions

Stage regulator of macroconidiation (MEDUSA/MedA family, DUF7082), inferred nuclear by phylogenetic descent: ACON-3 acts downstream of the fluffy master regulator and is required for later conidiation stages. Its molecular activity is uncharacterized, so no molecular_function is asserted.

References

📚 Additional Documentation

Notes

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