id: Q1K4S3
gene_symbol: glt-1
locus_tag: NCU01633
taxon:
  id: NCBITaxon:367110
  label: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
status: COMPLETE
description: The GO predictions describe supported biological properties at lower specificity than the
  current supported annotations.
source_documents:
- genes/NEUCR/glt-1/glt-1-protnlm-source.json
- genes/NEUCR/glt-1/glt-1-protnlm-provenance.json
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-09
  source_reference_id: file:NEUCR/glt-1/glt-1-protnlm-source.json
  predicted_term:
    id: GO:0022857
    label: transmembrane transporter activity
  predicted_term_type: GO_MF
  review:
    assessment: LSP
    confidence_score: 2
    summary: Heterologous radiotracer uptake and growth complementation establish D-glucose transport
      by GLT-1 (PMID:24581151); the later kinetic study identifies it as the low-affinity glucose transporter.
      Generic transmembrane transporter activity is correct but less precise than the supported D-glucose
      activity. This judgment concerns solute transport, not proton coupling.
    supported_by: &id001
    - reference_id: PMID:24581151
      supporting_text: We conclude that NCU01633 is a D-glucose transporter of N. crassa, which was therefore
        named as D-glucose transporter 1 (GLT-1).
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-09
  source_reference_id: file:NEUCR/glt-1/glt-1-protnlm-source.json
  predicted_term:
    id: GO:0016020
    label: membrane
  predicted_term_type: GO_CC
  review:
    assessment: LSP
    confidence_score: 2
    summary: The MFS membrane-spanning architecture and uptake of extracellular glucose support membrane
      residence, with plasma membrane inferred from the demonstrated physiological transport route. Membrane
      is therefore less precise than the supported plasma-membrane assignment. The specific compartment
      is a functional inference, not a claimed native imaging result.
    supported_by: *id001
references:
- id: PMID:24581151
  title: Transcriptional comparison of the filamentous fungus Neurospora crassa growing on three major
    monosaccharides D-glucose, D-xylose and L-arabinose.
  findings: []
  full_text_unavailable: false