id: Q7S7W0
gene_symbol: kal-1
taxon:
  id: NCBITaxon:367110
  label: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
status: COMPLETE
description: The emitted broad GO predictions are supported but less precise than existing defensible
  annotations.
source_documents:
- genes/NEUCR/kal-1/kal-1-protnlm-source.json
- genes/NEUCR/kal-1/kal-1-uniprot.txt
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-09
  source_reference_id: file:NEUCR/kal-1/kal-1-protnlm-source.json
  predicted_term:
    id: GO:0003677
    label: DNA binding
  predicted_term_type: GO_MF
  review:
    assessment: LSP
    confidence_score: 2
    summary: A conserved homeodomain is explicitly assigned to KAL-1 by Pfam and PROSITE, providing sequence
      evidence for DNA binding. The curated phylogenetic annotation specifies RNA polymerase II cis-regulatory
      region sequence-specific DNA binding. Generic DNA binding is consequently supported but less precise
      than that existing annotation. No particular DNA sequence preference is assigned here.
    supported_by:
    - reference_id: file:NEUCR/kal-1/kal-1-uniprot.txt
      supporting_text: DR   Pfam; PF00046; Homeodomain; 1.
    - reference_id: file:NEUCR/kal-1/kal-1-uniprot.txt
      supporting_text: DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific
        DNA binding; IBA:GO_Central.
references:
- id: file:NEUCR/kal-1/kal-1-uniprot.txt
  title: kal-1-uniprot.txt
  findings: []