ID   Q7S7W0_NEUCR            Unreviewed;       615 AA.
AC   Q7S7W0;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   15-DEC-2003, sequence version 1.
DT   10-JUN-2026, entry version 133.
DE   SubName: Full=Homeobox domain-containing protein {ECO:0000313|EMBL:EAA32084.1};
GN   Name=kal-1 {ECO:0000313|EMBL:EAA32084.1};
GN   ORFNames=NCU03593 {ECO:0000313|EMBL:EAA32084.1};
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA32084.1, ECO:0000313|Proteomes:UP000001805};
RN   [1] {ECO:0000313|EMBL:EAA32084.1, ECO:0000313|Proteomes:UP000001805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC   {ECO:0000313|Proteomes:UP000001805};
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA   FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA   Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA   Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA   Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA   Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA   Lander E.S., Nusbaum C., Birren B.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR   EMBL; CM002240; EAA32084.1; -; Genomic_DNA.
DR   RefSeq; XP_961320.1; XM_956227.2.
DR   AlphaFoldDB; Q7S7W0; -.
DR   STRING; 367110.Q7S7W0; -.
DR   PaxDb; 367110-Q7S7W0; -.
DR   GeneID; 3877484; -.
DR   KEGG; ncr:NCU03593; -.
DR   VEuPathDB; FungiDB:NCU03593; -.
DR   HOGENOM; CLU_023524_1_0_1; -.
DR   InParanoid; Q7S7W0; -.
DR   OMA; SHADPMI; -.
DR   OrthoDB; 6159439at2759; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR001356; HD.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR051000; Homeobox_DNA-bind_prot.
DR   InterPro; IPR009057; Homeodomain-like_sf.
DR   InterPro; IPR057939; TRF2_HOY1_PH.
DR   PANTHER; PTHR24324:SF5; HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX; 1.
DR   PANTHER; PTHR24324; HOMEOBOX PROTEIN HHEX; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF24818; PH_TRF2_HOY1; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000001805}.
FT   DOMAIN          75..135
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        77..136
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          1..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..10
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..37
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   615 AA;  68037 MW;  BEBCCFDE5E61B3BE CRC64;
     MATDIINQET LAPPSMKQEA PSPTSSMTPL PTPTSTSCPK DSVSPSPSTP ANGNKNHNQS
     SASRRPPRKS TLTQQQKNQK RQRATQDQLT TLEMEFNKNP TPTATVRERI AEEINMTERS
     VQIWFQNRRA KIKLLAKKSL ESGEDMDSIP ESMRQYLAIQ AMESGKGLGY FGRTGLLPYG
     HQGMLGGEQG GQGKVLIHHL TCKSLTIGKW MRVSQNSMDL IIFYSPDKCT MTYYINNEQE
     GYKIEYPFSY IKNIYLNNGD GDHMGGITIE LLHPPLFFMD AAGQASGFFQ VGDFTEDQQA
     SSVLTHHLGG NPKILSGQLA KLVSLEAFMH RHSPNHMFQE MHHPMALSAP VSPARPSSQP
     NFAQPHVGMF QENQWGINVH QNNNMMMRGG PGHKRQRSRS VPGPIDFQTL QMLQQPPSFH
     ITQPEHQQAP VHNPQIFAPI PQQPNMLGPL NPNLRIDTQA GFGSVDMRQY PMSATTAPHS
     PAGFNSPNYF APPDNGNMAG SFTPYSATFS PMINPSSLGV PPPSISPLSF DHPAIMSESP
     PMSMPPICEG SAISDDGSTH DMYQPGKHSY TLPMHPHSPF AEPNQAEMEL NQYMDLKHFD
     VDPASLSPES IHHTQ
//