id: Q7SCX0
gene_symbol: vtc-4
locus_tag: NCU08110
taxon:
  id: NCBITaxon:367110
  label: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
status: COMPLETE
description: The GO predictions describe supported biological properties at lower specificity than the
  current supported annotations.
source_documents:
- genes/NEUCR/vtc-4/vtc-4-protnlm-source.json
- genes/NEUCR/vtc-4/vtc-4-protnlm-provenance.json
- genes/NEUCR/vtc-4/vtc-4-primary-excerpts.md
predictions:
- source_method: ProtNLM2
  source_version: UniProt API snapshot 2026-09-09
  source_reference_id: file:NEUCR/vtc-4/vtc-4-protnlm-source.json
  predicted_term:
    id: GO:0005774
    label: vacuolar membrane
  predicted_term_type: GO_CC
  review:
    assessment: LSP
    confidence_score: 2
    summary: Native tagged VTC-4 localizes with vacuolar ATPase to prevacuolar compartments and the vacuolar
      network (PMID:26453652, full-text localization section). This directly supports membrane residence
      of the target VTC protein and agrees with characterized fungal VTC architecture. The existing fungal-type
      vacuole membrane annotation is more precise than generic vacuolar membrane.
    supported_by:
    - reference_id: PMID:26453652
      supporting_text: 'Vacuolar

        membrane proteins, such as the vacuolar ATPase (VMA-1) and the polyphosphate

        polymerase (VTC-4), were observed in the PVCs.'
    - reference_id: file:NEUCR/vtc-4/vtc-4-primary-excerpts.md
      supporting_text: both tagged proteins in the PVCs and the tubular vacuolar network
references:
- id: PMID:26453652
  title: Characterization of a Novel Prevacuolar Compartment in Neurospora crassa.
  findings: []
  full_text_unavailable: true
- id: file:NEUCR/vtc-4/vtc-4-primary-excerpts.md
  title: vtc-4-primary-excerpts.md
  findings: []