Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0009882 blue light photoreceptor activity	IDA PMID:20813262 Photoadaptation in Neurospora by competitive interaction of ...	NEW	Summary: Proposed new annotation. WC-1 is the LOV-domain photosensor of the WCC; this molecular function is absent from GOA despite being the gene's defining activity. Reason: The WCC's light response is mediated by its LOV domains, and WC-1 is the LOV-containing subunit; light triggers LOV-dependent WCC dimerization. GOA carries only the downstream transcription terms, leaving the photoreceptor activity itself unannotated. Supporting Evidence: PMID:20813262 Light responses and photoadaptation of Neurospora depend on the photosensory light-oxygen-voltage (LOV) domains of the circadian transcription factor White Collar Complex (WCC) and its negative regulator VIVID (VVD). PMID:20813262 We found that light triggers LOV-mediated dimerization of the WCC. PMID:20733070 the white collar complex (WCC), the primary blue-light photoreceptor and the transcription factor complex that initiates light-regulated transcriptional responses in Neurospora
GO:0005634 nucleus	IBA GO_REF:0000033	ACCEPT	Summary: Accept: nucleus. Reason: The White Collar Complex acts on target promoters in the nucleus, and is_active_in is the right qualifier for the site of WC-1's transcriptional activity.
GO:0005634 nucleus	IEA GO_REF:0000044	ACCEPT	Summary: Accept: nucleus. Reason: Electronic route to the same nuclear location as the IBA row; redundant with it.
GO:0006355 regulation of DNA-templated transcription	IEA GO_REF:0000002	ACCEPT	Summary: Accept: regulation of DNA-templated transcription. Reason: Generic parent. WC-1's characterised role is light-driven activation of clock and photoresponse genes as part of the WCC.
GO:0008270 zinc ion binding	IEA GO_REF:0000002	ACCEPT	Summary: Accept: zinc ion binding. Reason: Zinc is structural to the GATA-type finger that mediates WC-1's DNA binding; a cofactor requirement rather than a separate function.
GO:0043565 sequence-specific DNA binding	IEA GO_REF:0000002	ACCEPT	Summary: Accept: sequence-specific DNA binding. Reason: The GATA finger binds specific promoter elements, so this is more informative than bare DNA binding. The LOV-domain photoreceptor activity that distinguishes WC-1 from WC-2 is annotated separately in this review.
GO:0005515 protein binding	IPI PMID:19427309 Activity of the circadian transcription factor White Collar ...	KEEP AS NON CORE	Summary: Protein binding (uninformative MF) reflecting White Collar Complex / clock interactions. Reason: Interaction evidence from the study of WCC phosphorylation at SP motifs, i.e. WC-1 with its complex partner and regulatory kinases. Real, but 'protein binding' names no function; the informative statement is WCC membership, annotated separately.
GO:0005515 protein binding	IPI PMID:20733070 Physical interaction between VIVID and white collar complex ...	KEEP AS NON CORE	Summary: Protein binding (uninformative MF) reflecting White Collar Complex / clock interactions. Reason: Interaction evidence for the VIVID-WCC association that mediates photoadaptation. Kept as non-core because the term records that a partner exists without saying what WC-1 does.
GO:0005515 protein binding	IPI PMID:20807745 VIVID interacts with the WHITE COLLAR complex and FREQUENCY-...	KEEP AS NON CORE	Summary: Protein binding (uninformative MF) reflecting White Collar Complex / clock interactions. Reason: Interaction evidence placing WC-1 in the VIVID/WCC/FRH network that shapes light and clock responses; again a partner list rather than a molecular function.
GO:0005515 protein binding	IPI PMID:20813262 Photoadaptation in Neurospora by competitive interaction of ...	KEEP AS NON CORE	Summary: Protein binding (uninformative MF) reflecting White Collar Complex / clock interactions. Reason: Interaction evidence from the competitive LOV-domain model of photoadaptation, where VIVID competes with WC-1's own LOV domain. The mechanistic content sits in the photoreceptor annotation, not in this bare binding term.

Core Functions

Blue-light photoreceptor and light-responsive transcription factor: WC-1, via its LOV domain, senses blue light and (in the White Collar Complex with WC-2) activates light-induced gene expression, clock entrainment and light gating of conidiation.

Molecular Function:

blue light photoreceptor activity

Directly Involved In:

regulation of DNA-templated transcription

Cellular Locations:

nucleus

Supporting Evidence:

PMID:20733070
the white collar complex (WCC), the primary blue-light photoreceptor and the transcription factor complex that initiates light-regulated transcriptional responses in Neurospora
PMID:20813262
Light responses and photoadaptation of Neurospora depend on the photosensory light-oxygen-voltage (LOV) domains of the circadian transcription factor White Collar Complex (WCC) and its negative regulator VIVID (VVD).

References

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Notes

(wc-1-notes.md)

wc-1 / white collar-1 (Neurospora crassa) — curation notes

UniProt Q01371. GATA-type TF + LOV blue-light photoreceptor; White Collar Complex. Neurospora variant, light/clock-gating tier.
- Principal blue-light photoreceptor; with WC-2 forms the WCC mediating Neurospora photoresponses. PMID:14618260.
- Core MF proposed GO:0009882 blue light photoreceptor activity. Protein-binding IPIs kept non-core (WCC interactions).

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