Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0000976 transcription cis-regulatory region binding	IBA GO_REF:0000033	ACCEPT	Summary: Accept: transcription cis-regulatory region binding. Reason: WC-2 partners WC-1 in the White Collar Complex, which occupies the cis-regulatory elements of light-induced genes; the cis-regulatory term is the appropriate binding statement.
GO:0005634 nucleus	IBA GO_REF:0000033	ACCEPT	Summary: Accept: nucleus. Reason: The WCC operates on nuclear promoters, and is_active_in matches the site of the regulatory activity.
GO:0006357 regulation of transcription by RNA polymerase II	IBA GO_REF:0000033	ACCEPT	Summary: Accept: regulation of transcription by RNA polymerase II. Reason: Pol II-specific regulation, matching the WCC's role as the light-responsive activator of clock and photoresponse genes.
GO:0005634 nucleus	IEA GO_REF:0000044	ACCEPT	Summary: Accept: nucleus. Reason: Electronic route to the same nuclear location as the IBA row; concordant and redundant.
GO:0006355 regulation of DNA-templated transcription	IEA GO_REF:0000002	ACCEPT	Summary: Accept: regulation of DNA-templated transcription. Reason: Unsigned generic parent of the Pol II term above; retained, but uninformative.
GO:0008270 zinc ion binding	IEA GO_REF:0000002	ACCEPT	Summary: Accept: zinc ion binding. Reason: Structural zinc of the GATA-type finger that gives WC-2 its DNA-binding capacity.
GO:0043565 sequence-specific DNA binding	IEA GO_REF:0000002	ACCEPT	Summary: Accept: sequence-specific DNA binding. Reason: Sequence-specific binding via the GATA-type zinc finger. Electronic (IEA) inference from the domain; no WC-2 binding-site selection assay is cited here.
GO:0005515 protein binding	IPI PMID:19427309 Activity of the circadian transcription factor White Collar ...	KEEP AS NON CORE	Summary: Protein binding (uninformative MF) reflecting White Collar Complex / clock interactions. Reason: Interaction evidence from the study of WCC phosphorylation at SP motifs, i.e. WC-2 with WC-1 and associated kinases. Real, but 'protein binding' names no function; WCC membership is the informative statement and is annotated separately.
GO:0005515 protein binding	IPI PMID:20733070 Physical interaction between VIVID and white collar complex ...	KEEP AS NON CORE	Summary: Protein binding (uninformative MF) reflecting White Collar Complex / clock interactions. Reason: Interaction evidence for the VIVID-WCC association underlying photoadaptation. Kept as non-core because the term records the existence of a partner rather than what WC-2 does.
GO:0005515 protein binding	IPI PMID:20807745 VIVID interacts with the WHITE COLLAR complex and FREQUENCY-...	KEEP AS NON CORE	Summary: Protein binding (uninformative MF) reflecting White Collar Complex / clock interactions. Reason: Interaction evidence placing WC-2 in the VIVID/WCC/FRH network that alters light and clock responses; a partner list rather than a molecular function.

Core Functions

White Collar Complex transcription factor: WC-2, a GATA-type factor, dimerizes with WC-1 to form the WCC that activates light-induced transcription, clock entrainment and light gating of conidiation.

Directly Involved In:

regulation of transcription by RNA polymerase II

Cellular Locations:

nucleus

Supporting Evidence:

PMID:19427309
The White Collar Complex (WCC) is the central transcription factor of the circadian clock of Neurospora crassa.
PMID:19427309
Exchange of a single WC-2 serine residue (S433) to alanine or aspartate affects WCC-dependent transcription and circadian period
PMID:20733070
the white collar complex (WCC), the primary blue-light photoreceptor and the transcription factor complex that initiates light-regulated transcriptional responses in Neurospora

References

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📚 Additional Documentation

Notes

(wc-2-notes.md)

wc-2 / white collar-2 (Neurospora crassa) — curation notes

UniProt P78714. GATA-type TF; White Collar Complex partner. Neurospora variant, light/clock-gating tier.
- Dimerizes with WC-1 to form the WCC, master activator of light-induced transcription; entrains the clock and gates conidiation. PMID:14618260.
- Protein-binding IPIs kept non-core (WCC interactions).

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