id: A0A2R9CAF4
gene_symbol: A0A2R9CAF4
taxon:
  id: NCBITaxon:9597
  label: Pan paniscus
status: COMPLETE
description: >-
  The SLC26-family membrane architecture supports anion transport. Both predictions are broader than existing
  specific transport or membrane-localization annotations.
source_documents:
  - genes/PANPA/A0A2R9CAF4/A0A2R9CAF4-uniprot.txt
  - genes/PANPA/A0A2R9CAF4/A0A2R9CAF4-goa.tsv
  - publications/PMID_42509233.md
predictions:
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0008509
      label: monoatomic anion transmembrane transporter activity
    predicted_term_type: GO_MF
    review:
      assessment: LSP
      confidence_score: 2
      summary: >-
        The target has the SLC26/SulP transport domain, multiple transmembrane segments, and a STAS domain.
        Experimental characterization of SLC26A11 supports chloride conduction as well as sulfate transport
        (PMID:42509233), providing family-level grounding for anion transport. The cached target annotations
        include the more specific chloride channel activity. The generic anion-transporter prediction
        is therefore supported but less precise.
      supported_by:
        - reference_id: file:PANPA/A0A2R9CAF4/A0A2R9CAF4-uniprot.txt
          supporting_text: >-
            ID   A0A2R9CAF4_PANPA        Unreviewed;       606 AA. ... DR   InterPro; IPR001902; SLC26A/SulP_fam.
            ... DR   InterPro; IPR002645; STAS_dom. ... FT   TRANSMEM        52..70 ... FT   TRANSMEM        76..94
            ... FT   TRANSMEM        123..144 ... FT   TRANSMEM        156..179 ... FT   TRANSMEM        199..218
            ... FT   TRANSMEM        239..262 ... FT   TRANSMEM        308..329 ... FT   TRANSMEM        341..360
            ... FT   TRANSMEM        398..419 ... FT   TRANSMEM        440..465 ... FT   DOMAIN          480..564
            ... FT                   /note="STAS"
        - reference_id: PMID:42509233
          supporting_text: >-
            both a sulfate transporter and a chloride channel
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0016020
      label: membrane
    predicted_term_type: GO_CC
    review:
      assessment: LSP
      confidence_score: 2
      summary: >-
        Multiple transmembrane segments in the target provide direct sequence-architecture support for
        membrane residence. This agrees with the membrane transport behavior characterized for SLC26A11
        (PMID:42509233). The cached annotations identify specific membranes, including lysosomal and plasma
        membranes. Membrane is a valid but less precise localization and is not an error merely because
        it is broad.
      supported_by:
        - reference_id: file:PANPA/A0A2R9CAF4/A0A2R9CAF4-uniprot.txt
          supporting_text: >-
            ID   A0A2R9CAF4_PANPA        Unreviewed;       606 AA. ... DR   InterPro; IPR001902; SLC26A/SulP_fam.
            ... DR   InterPro; IPR002645; STAS_dom. ... FT   TRANSMEM        52..70 ... FT   TRANSMEM        76..94
            ... FT   TRANSMEM        123..144 ... FT   TRANSMEM        156..179 ... FT   TRANSMEM        199..218
            ... FT   TRANSMEM        239..262 ... FT   TRANSMEM        308..329 ... FT   TRANSMEM        341..360
            ... FT   TRANSMEM        398..419 ... FT   TRANSMEM        440..465 ... FT   DOMAIN          480..564
            ... FT                   /note="STAS"
        - reference_id: PMID:42509233
          supporting_text: >-
            both a sulfate transporter and a chloride channel
references:
  - id: file:PANPA/A0A2R9CAF4/A0A2R9CAF4-uniprot.txt
    title: A0A2R9CAF4-uniprot.txt
  - id: PMID:42509233
    title: SLC26A11 is an atypical solute carrier with dual transport-channel function mediating
      lysosomal sulfate transport.