id: A0BFB4
gene_symbol: A0BFB4
taxon:
  id: NCBITaxon:5888
  label: Paramecium tetraurelia
status: COMPLETE
description: >-
  The conserved protein kinase domain and active-site signatures support participation in protein phosphorylation.
source_documents:
  - genes/PARTE/A0BFB4/A0BFB4-uniprot.txt
  - genes/PARTE/A0BFB4/A0BFB4-goa.tsv
predictions:
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0006468
      label: protein phosphorylation
    predicted_term_type: GO_BP
    review:
      assessment: COR
      confidence_score: 2
      summary: >-
        The target has a protein kinase domain at residues 96–348 together with protein-kinase ATP-binding
        and serine/threonine-kinase active-site signatures. These features support the curated IBA protein
        serine/threonine kinase activity and provide a mechanistic basis for protein phosphorylation.
        The process term itself is absent from the cached annotations, so the prediction adds an explicit
        biological-process annotation. It follows from the supported catalytic activity and does not identify
        a new substrate or autophagy mechanism.
      supported_by:
        - reference_id: file:PARTE/A0BFB4/A0BFB4-uniprot.txt
          supporting_text: >-
            ID   A0BFB4_PARTE            Unreviewed;       381 AA. ... DR   GO; GO:0005776; C:autophagosome;
            IBA:GO_Central. ... DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central. ... DR   GO; GO:0005829;
            C:cytosol; IBA:GO_Central. ... DR   GO; GO:0016020; C:membrane; IBA:GO_Central. ... DR   GO;
            GO:0000407; C:phagophore assembly site; IBA:GO_Central. ... DR   GO; GO:0004674; F:protein
            serine/threonine kinase activity; IBA:GO_Central. ... DR   GO; GO:0000045; P:autophagosome
            assembly; IBA:GO_Central. ... DR   GO; GO:0010506; P:regulation of autophagy; IBA:GO_Central.
            ... DR   InterPro; IPR000719; Prot_kinase_dom. ... DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
            ... DR   InterPro; IPR008271; Ser/Thr_kinase_AS. ... FT   DOMAIN          96..348 ... FT                   /note="Protein
            kinase"
references:
  - id: file:PARTE/A0BFB4/A0BFB4-uniprot.txt
    title: A0BFB4-uniprot.txt