PP_2634

UniProt ID: Q88JL5
Organism: Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)
Review Status: DRAFT
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Gene Description

PP_2634 encodes a BcsQ/YhjQ-family P-loop NTPase accessory factor in the local bacterial cellulose synthase operon. Despite the generic UniProt submitted name "Cellulose synthase", its domain architecture and operon context support a non-catalytic BcsQ role in organizing or positioning the cellulose synthase/secretion machinery rather than polymerizing cellulose.

Existing Annotations Review

GO Term Evidence Action Reason
GO:0030244 cellulose biosynthetic process
ISS
PMID:19400787
BcsQ is an essential component of the Escherichia coli cellu... 		NEW
Summary: PP_2634 should be added to cellulose biosynthetic process as a BcsQ/YhjQ-family accessory factor, not as a catalytic cellulose synthase.
Reason: BcsQ/yhjQ is experimentally required for cellulose biosynthesis in E. coli, and PP_2634 has BcsQ/P-loop NTPase domain architecture in the KT2440 bcs operon immediately adjacent to bcsA/bcsB.
Supporting Evidence:
PMID:19400787
we show that yhjQ, but not yhjR, is essential for cellulose biosynthesis; it has therefore been renamed bcsQ
file:PSEPK/PP_2634/PP_2634-uniprot.txt
DR InterPro; IPR017746; Cellulose_synthase_operon_BcsQ.
file:PSEPK/PP_2634/PP_2634-deep-research-openscientist.md
PP_2634 is **BcsQ**, an accessory **MinD/ParA-family P-loop ATPase**

Core Functions

BcsQ/YhjQ-family accessory factor for spatial organization or assembly of the bacterial cellulose synthase/secretion machinery; not the catalytic cellulose synthase.

Directly Involved In:
cellulose biosynthetic process
Supporting Evidence:
  • file:PSEPK/PP_2634/PP_2634-uniprot.txt
    DR InterPro; IPR017746; Cellulose_synthase_operon_BcsQ.
  • file:PSEPK/PP_2634/PP_2634-uniprot.txt
    DR InterPro; IPR027417; P-loop_NTPase.
  • PMID:19400787
    we show that yhjQ, but not yhjR, is essential for cellulose biosynthesis; it has therefore been renamed bcsQ
  • file:PSEPK/PP_2634/PP_2634-deep-research-openscientist.md
    PP_2634 is **BcsQ**, an accessory **MinD/ParA-family P-loop ATPase**

References

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Suggested Questions for Experts

Q: Should UniProt update PP_2634's submitted/display name from "Cellulose synthase" to BcsQ or cellulose biosynthesis protein BcsQ?

Q: Does KT2440 PP_2634 localize the cellulose synthase machinery to a specific subcellular site as shown for enterobacterial BcsQ?

Suggested Experiments

Experiment: Delete PP_2634 in KT2440, complement with wild-type and Walker-A mutant variants, and assay cellulose production and biofilm/rhizosphere phenotypes.

Type: targeted genetics and cellulose phenotype assay

Experiment: Express a functional fluorescent PP_2634/BcsQ fusion and image localization relative to BcsA/BcsB and sites of cellulose deposition.

Type: live-cell localization assay

Deep Research

OpenScientist

(PP_2634-deep-research-openscientist.md)

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