aceF

Gene Description

aceF (PP_0338) encodes the E2 acetyltransferase component of the pyruvate dehydrogenase complex. The protein carries lipoyl domains and a catalytic acyltransferase domain that transfers the acetyl group from S-acetyldihydrolipoyllysine to coenzyme A, coupling the E1 pyruvate-decarboxylating reaction to acetyl-CoA formation. It is a cytoplasmic component of the multienzyme pyruvate dehydrogenase complex, connecting pyruvate produced by lower central carbon metabolism to acetyl-CoA and the TCA cycle.

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity	IEA GO_REF:0000120	ACCEPT	Summary: dihydrolipoyllysine-residue acetyltransferase activity is consistent with the curated UniProt name, EC/family evidence, and the gene product role summarized here. Reason: This is a specific, biologically appropriate annotation for this gene product.
GO:0005737 cytoplasm	IEA GO_REF:0000118	ACCEPT	Summary: cytoplasm is consistent with the curated UniProt name, EC/family evidence, and the gene product role summarized here. Reason: This is a specific, biologically appropriate annotation for this gene product.
GO:0006086 pyruvate decarboxylation to acetyl-CoA	IEA GO_REF:0000120	ACCEPT	Summary: pyruvate decarboxylation to acetyl-CoA is consistent with the curated UniProt name, EC/family evidence, and the gene product role summarized here. Reason: This is a specific, biologically appropriate annotation for this gene product.
GO:0016407 acetyltransferase activity	IEA GO_REF:0000118	KEEP AS NON CORE	Summary: acetyltransferase activity is biologically plausible for this enzyme but is ancillary to the more specific catalytic function. Reason: Retain as a supporting/non-core annotation rather than using it as the main functional summary.
GO:0016746 acyltransferase activity	IEA GO_REF:0000002	KEEP AS NON CORE	Summary: acyltransferase activity is biologically plausible for this enzyme but is ancillary to the more specific catalytic function. Reason: Retain as a supporting/non-core annotation rather than using it as the main functional summary.
GO:0031405 lipoic acid binding	IEA GO_REF:0000118	KEEP AS NON CORE	Summary: lipoic acid binding is biologically plausible for this enzyme but is ancillary to the more specific catalytic function. Reason: Retain as a supporting/non-core annotation rather than using it as the main functional summary.
GO:0045254 pyruvate dehydrogenase complex	IEA GO_REF:0000120	ACCEPT	Summary: pyruvate dehydrogenase complex is consistent with the curated UniProt name, EC/family evidence, and the gene product role summarized here. Reason: This is a specific, biologically appropriate annotation for this gene product.

Core Functions

dihydrolipoyllysine-residue acetyltransferase activity supporting the Acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12) role summarized for aceF.

Molecular Function:

dihydrolipoyllysine-residue acetyltransferase activity

Directly Involved In:

pyruvate decarboxylation to acetyl-CoA

Supporting Evidence:

file:PSEPK/aceF/aceF-uniprot.txt
DR GO; GO:0004742; F:dihydrolipoyllysine-residue acetyltransferase activity; IEA:UniProtKB-UniRule.

Gene Description

Existing Annotations Review

Core Functions

dihydrolipoyllysine-residue acetyltransferase activity supporting the Acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12) role summarized for aceF.

References

Deep Research

Asta

OpenScientist

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