algC (PP_5288) encodes a bifunctional phosphomannomutase/phosphoglucomutase. It interconverts mannose 6-phosphate with mannose 1-phosphate and glucose 6-phosphate with glucose 1-phosphate, supplying sugar-phosphate precursors for GDP-mannose, lipopolysaccharide, and related cell-envelope carbohydrate biosynthesis. It is not a core ED enzyme but draws on the same hexose-phosphate pools.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000287 magnesium ion binding | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: magnesium ion binding is biologically plausible for this enzyme but is ancillary to the more specific catalytic function. Reason: Retain as a supporting/non-core annotation rather than using it as the main functional summary. |
| GO:0004614 phosphoglucomutase activity | IEA GO_REF:0000120 | ACCEPT | Summary: phosphoglucomutase activity is consistent with the curated UniProt name, EC/family evidence, and the gene product role summarized here. Reason: This is a specific, biologically appropriate annotation for this gene product. |
| GO:0004615 phosphomannomutase activity | IEA GO_REF:0000120 | ACCEPT | Summary: phosphomannomutase activity is consistent with the curated UniProt name, EC/family evidence, and the gene product role summarized here. Reason: This is a specific, biologically appropriate annotation for this gene product. |
| GO:0005975 carbohydrate metabolic process | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: carbohydrate metabolic process is biologically plausible for this enzyme but is ancillary to the more specific catalytic function. Reason: Retain as a supporting/non-core annotation rather than using it as the main functional summary. |
| GO:0016868 intramolecular phosphotransferase activity | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: intramolecular phosphotransferase activity is biologically plausible for this enzyme but is ancillary to the more specific catalytic function. Reason: Retain as a supporting/non-core annotation rather than using it as the main functional summary. |
| GO:1901137 carbohydrate derivative biosynthetic process | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: carbohydrate derivative biosynthetic process is biologically plausible for this enzyme but is ancillary to the more specific catalytic function. Reason: Retain as a supporting/non-core annotation rather than using it as the main functional summary. |
| GO:0009103 lipopolysaccharide biosynthetic process | IEA GO_REF:0000041 | ACCEPT | Summary: lipopolysaccharide biosynthetic process is consistent with the curated UniProt name, EC/family evidence, and the gene product role summarized here. Reason: This is a specific, biologically appropriate annotation for this gene product. |
| GO:0009298 GDP-mannose biosynthetic process | IEA GO_REF:0000041 | ACCEPT | Summary: GDP-mannose biosynthetic process is consistent with the curated UniProt name, EC/family evidence, and the gene product role summarized here. Reason: This is a specific, biologically appropriate annotation for this gene product. |
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Download this section (compressed HTML)Q: What fraction of glucose 1-phosphate and mannose 1-phosphate flux is supplied by AlgC relative to the dedicated Pgm and CpsG paralogs in KT2440?
Experiment: Compare substrate kinetics for purified AlgC and measure nucleotide-sugar flux in single and combined algC, pgm, and cpsG perturbations.
Type: comparative enzymology and metabolic flux analysis
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