# Citations for Research Query

**Query:** # Gene Research for Functional Annotation

## ⚠️ CRITICAL: Gene/Protein Identification Context

**BEFORE YOU BEGIN RESEARCH:** You MUST verify you are researching the CORRECT gene/protein. Gene symbols can be ambiguous, especially for less well-characterized genes from non-model organisms.

### Target Gene/Protein Identity (from UniProt):
- **UniProt Accession:** Q88NC4
- **Protein Description:** RecName: Full=GDP-mannose 6-dehydrogenase; Short=GMD; EC=1.1.1.132;
- **Gene Information:** Name=algD; OrderedLocusNames=PP_1288;
- **Organism (full):** Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440).
- **Protein Family:** Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
- **Key Domains:** 6-PGluconate_DH-like_C_sf. (IPR008927); GDPman_DH. (IPR028358); NAD(P)-bd_dom_sf. (IPR036291); UDP-Glc/GDP-Man. (IPR017476); UDP-Glc/GDP-Man_DH_C. (IPR014027)

### MANDATORY VERIFICATION STEPS:

1. **Check if the gene symbol "algD" matches the protein description above**
2. **Verify the organism is correct:** Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440).
3. **Check if protein family/domains align with what you find in literature**
4. **If you find literature for a DIFFERENT gene with the same or similar symbol, STOP**

### If Gene Symbol is Ambiguous or You Cannot Find Relevant Literature:

**DO NOT PROCEED WITH RESEARCH ON A DIFFERENT GENE.** Instead:
- State clearly: "The gene symbol 'algD' is ambiguous or literature is limited for this specific protein"
- Explain what you found (e.g., "Found extensive literature on a different gene with the same symbol in a different organism")
- Describe the protein based ONLY on the UniProt information provided above
- Suggest that the protein function can be inferred from domain/family information

### Research Target:

Please provide a comprehensive research report on the gene **algD** (gene ID: algD, UniProt: Q88NC4) in PSEPK.

The research report should be a detailed narrative explaining the function, biological processes, and localization of the gene product. Citations should be given for all claims.

You should prioritize authoritative reviews and primary scientific literature when conducting research. You can supplement
this with annotations you find in gene/protein databases, but these can be outdated or inaccurate.

We are specifically interested in the primary function of the gene - for enzymes, what reaction is catalyzed, and what is the substrate specificity? For transporters, what is the substrate? For structural proteins or adapters, what is the broader structural role? For signaling molecules, what is the role in the pathway.

We are interested in where in or outside the cell the gene product carries out its function.

We are also interested in the signaling or biochemical pathways in which the gene functions. We are less interested in broad pleiotropic effects, except where these elucidate the precise role.

Include evidence where possible. We are interested in both experimental evidence as well as inference from structure, evolution, or bioinformatic analysis. Precise studies should be prioritized over high-throughput, where available.
**Provider:** openai
**Generated:** 2026-03-21T00:06:16.756221

1. AnnotationURLCitation(end_index=486, start_index=315, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=Alginates%20play%20an%20important%20role,that%20the%20substrate%20oxidation%20reaction')
2. AnnotationURLCitation(end_index=823, start_index=665, title='GDP-mannose dehydrogenase is the key regulatory enzyme in alginate biosynthesis in Pseudomonas aeruginosa: evidence from metabolite studies - PubMed', type='url_citation', url='https://pubmed.ncbi.nlm.nih.gov/7521247/#:~:text=The%20Pseudomonas%20aeruginosa%20enzyme%20GDP,of%20the%20key%20metabolites%20GDP')
3. AnnotationURLCitation(end_index=1296, start_index=1139, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=48%2C000%20Daltons%20molecular%20weight%20polypeptide%2C,swapped%20dimer')
4. AnnotationURLCitation(end_index=1652, start_index=1461, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=adenine%20dinucleotide%20%28NAD%5E%7B%2B%7D%29%2C%20the%20carboxy,contributing%20to%20each%20active%20site')
5. AnnotationURLCitation(end_index=2021, start_index=1845, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=strains%20exhibits%20strong%20negative%20cooperativity,mannose%20dehydrogenase%20inhibition')
6. AnnotationURLCitation(end_index=2381, start_index=2205, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=strains%20exhibits%20strong%20negative%20cooperativity,mannose%20dehydrogenase%20inhibition')
7. AnnotationURLCitation(end_index=2740, start_index=2569, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=Alginates%20play%20an%20important%20role,that%20the%20substrate%20oxidation%20reaction')
8. AnnotationURLCitation(end_index=2899, start_index=2741, title='GDP-mannose dehydrogenase is the key regulatory enzyme in alginate biosynthesis in Pseudomonas aeruginosa: evidence from metabolite studies - PubMed', type='url_citation', url='https://pubmed.ncbi.nlm.nih.gov/7521247/#:~:text=The%20Pseudomonas%20aeruginosa%20enzyme%20GDP,of%20the%20key%20metabolites%20GDP')
9. AnnotationURLCitation(end_index=3153, start_index=2985, title='Colony morphology and transcriptome profiling of Pseudomonas putida KT2440 and its mutants deficient in alginate or all EPS synthesis under controlled matric potentials - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC4287175/#:~:text=no%20genes%20except%20galU%20were,gene%2C%20annotated%20as%20asparagine%20synthetase')
10. AnnotationURLCitation(end_index=3555, start_index=3398, title='Colony morphology and transcriptome profiling of Pseudomonas putida KT2440 and its mutants deficient in alginate or all EPS synthesis under controlled matric potentials - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC4287175/#:~:text=to%20produce%20alginate%2C%20a%20major,to%20alleviate%20the%20effect%20of')
11. AnnotationURLCitation(end_index=3923, start_index=3746, title='Advances in alginate biosynthesis: regulation and production in Azotobacter vinelandii - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC12350332/#:~:text=Alginates%20are%20polysaccharides%20composed%20of,GMP.%20This%20regulatory%20network%20links')
12. AnnotationURLCitation(end_index=4243, start_index=4117, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=infection%20,acetylation%20%5B5%20%2C%208')
13. AnnotationURLCitation(end_index=4482, start_index=4244, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=Synthetic%20scheme%20of%20alginate%20biosynthesis,triphosphate%2C%20NAD%E2%80%94Nicotinamide%20adenine%20dinucleotide%2C%20LPS%E2%80%94Lipopolysaccharide')
14. AnnotationURLCitation(end_index=4906, start_index=4748, title='GDP-mannose dehydrogenase is the key regulatory enzyme in alginate biosynthesis in Pseudomonas aeruginosa: evidence from metabolite studies - PubMed', type='url_citation', url='https://pubmed.ncbi.nlm.nih.gov/7521247/#:~:text=The%20Pseudomonas%20aeruginosa%20enzyme%20GDP,of%20the%20key%20metabolites%20GDP')
15. AnnotationURLCitation(end_index=5230, start_index=5072, title='GDP-mannose dehydrogenase is the key regulatory enzyme in alginate biosynthesis in Pseudomonas aeruginosa: evidence from metabolite studies - PubMed', type='url_citation', url='https://pubmed.ncbi.nlm.nih.gov/7521247/#:~:text=The%20Pseudomonas%20aeruginosa%20enzyme%20GDP,of%20the%20key%20metabolites%20GDP')
16. AnnotationURLCitation(end_index=6114, start_index=5876, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=Synthetic%20scheme%20of%20alginate%20biosynthesis,triphosphate%2C%20NAD%E2%80%94Nicotinamide%20adenine%20dinucleotide%2C%20LPS%E2%80%94Lipopolysaccharide')
17. AnnotationURLCitation(end_index=6488, start_index=6250, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=Synthetic%20scheme%20of%20alginate%20biosynthesis,triphosphate%2C%20NAD%E2%80%94Nicotinamide%20adenine%20dinucleotide%2C%20LPS%E2%80%94Lipopolysaccharide')
18. AnnotationURLCitation(end_index=6772, start_index=6601, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=Alginates%20play%20an%20important%20role,that%20the%20substrate%20oxidation%20reaction')
19. AnnotationURLCitation(end_index=7095, start_index=6924, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=Alginates%20play%20an%20important%20role,that%20the%20substrate%20oxidation%20reaction')
20. AnnotationURLCitation(end_index=7730, start_index=7492, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=Synthetic%20scheme%20of%20alginate%20biosynthesis,triphosphate%2C%20NAD%E2%80%94Nicotinamide%20adenine%20dinucleotide%2C%20LPS%E2%80%94Lipopolysaccharide')
21. AnnotationURLCitation(end_index=8197, start_index=7959, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=Synthetic%20scheme%20of%20alginate%20biosynthesis,triphosphate%2C%20NAD%E2%80%94Nicotinamide%20adenine%20dinucleotide%2C%20LPS%E2%80%94Lipopolysaccharide')
22. AnnotationURLCitation(end_index=8653, start_index=8509, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=Mannuronate%20is%20believed%20to%20be,7%2C6%20%2C%2014%2C11')
23. AnnotationURLCitation(end_index=9301, start_index=9143, title='GDP-mannose dehydrogenase is the key regulatory enzyme in alginate biosynthesis in Pseudomonas aeruginosa: evidence from metabolite studies - PubMed', type='url_citation', url='https://pubmed.ncbi.nlm.nih.gov/7521247/#:~:text=The%20Pseudomonas%20aeruginosa%20enzyme%20GDP,of%20the%20key%20metabolites%20GDP')
24. AnnotationURLCitation(end_index=9398, start_index=9302, title='GDP-mannose dehydrogenase is the key regulatory enzyme in alginate biosynthesis in Pseudomonas aeruginosa: evidence from metabolite studies - PubMed', type='url_citation', url='https://pubmed.ncbi.nlm.nih.gov/7521247/#:~:text=of%20P,mannuronate')
25. AnnotationURLCitation(end_index=9906, start_index=9746, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=GMD%20is%20currently%20believed%20to,of%20the%20integration%20host%20factor')
26. AnnotationURLCitation(end_index=10483, start_index=10377, title='Colony morphology and transcriptome profiling of Pseudomonas putida KT2440 and its mutants deficient in alginate or all EPS synthesis under controlled matric potentials - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC4287175/#:~:text=water%20limitation,peb')
27. AnnotationURLCitation(end_index=10760, start_index=10654, title='Colony morphology and transcriptome profiling of Pseudomonas putida KT2440 and its mutants deficient in alginate or all EPS synthesis under controlled matric potentials - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC4287175/#:~:text=water%20limitation,peb')
28. AnnotationURLCitation(end_index=11305, start_index=11137, title='Colony morphology and transcriptome profiling of Pseudomonas putida KT2440 and its mutants deficient in alginate or all EPS synthesis under controlled matric potentials - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC4287175/#:~:text=no%20genes%20except%20galU%20were,gene%2C%20annotated%20as%20asparagine%20synthetase')
29. AnnotationURLCitation(end_index=11650, start_index=11482, title='Colony morphology and transcriptome profiling of Pseudomonas putida KT2440 and its mutants deficient in alginate or all EPS synthesis under controlled matric potentials - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC4287175/#:~:text=support%20that%20alginate%20is%20an,other%20tolerance%20mechanisms%20are%20activated')
30. AnnotationURLCitation(end_index=11819, start_index=11651, title='Colony morphology and transcriptome profiling of Pseudomonas putida KT2440 and its mutants deficient in alginate or all EPS synthesis under controlled matric potentials - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC4287175/#:~:text=no%20genes%20except%20galU%20were,gene%2C%20annotated%20as%20asparagine%20synthetase')
31. AnnotationURLCitation(end_index=12310, start_index=12139, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=Alginates%20play%20an%20important%20role,that%20the%20substrate%20oxidation%20reaction')
32. AnnotationURLCitation(end_index=12600, start_index=12429, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=Alginates%20play%20an%20important%20role,that%20the%20substrate%20oxidation%20reaction')
33. AnnotationURLCitation(end_index=13237, start_index=13083, title='Advances in alginate biosynthesis: regulation and production in Azotobacter vinelandii - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC12350332/#:~:text=Alginates%20are%20linear%20biopolymers%20present,10%20N%C3%BA%C3%B1ez')
34. AnnotationURLCitation(end_index=13544, start_index=13390, title='Advances in alginate biosynthesis: regulation and production in Azotobacter vinelandii - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC12350332/#:~:text=Alginates%20are%20linear%20biopolymers%20present,10%20N%C3%BA%C3%B1ez')
35. AnnotationURLCitation(end_index=13728, start_index=13545, title='The sodium alginate-producing gene algD reduces Pseudomonas putida strain XMS-1-mediated Cd uptake in Lactuca sativa by increasing the relative abundances of Cd stabilization-related bacterial communities and functional genes - ScienceDirect', type='url_citation', url='https://www.sciencedirect.com/science/article/abs/pii/S0944501326000273#:~:text=immobilizing%20related%20abundant%20,on%20reducing%20Cd%20availability%20and')
36. AnnotationURLCitation(end_index=14425, start_index=14273, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=The%20biosynthetic%20pathway%20leading%20to,ManA%29%20%28Figure%201')
37. AnnotationURLCitation(end_index=14979, start_index=14741, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=Synthetic%20scheme%20of%20alginate%20biosynthesis,triphosphate%2C%20NAD%E2%80%94Nicotinamide%20adenine%20dinucleotide%2C%20LPS%E2%80%94Lipopolysaccharide')
38. AnnotationURLCitation(end_index=15221, start_index=15077, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=Mannuronate%20is%20believed%20to%20be,7%2C6%20%2C%2014%2C11')
39. AnnotationURLCitation(end_index=16614, start_index=16429, title='Colony morphology and transcriptome profiling of Pseudomonas putida KT2440 and its mutants deficient in alginate or all EPS synthesis under controlled matric potentials - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC4287175/#:~:text=Interestingly%2C%20alginate%20synthesis%20regulatory%20genes,in%20the%20alginate%20synthesis%20operon')
40. AnnotationURLCitation(end_index=16957, start_index=16772, title='Colony morphology and transcriptome profiling of Pseudomonas putida KT2440 and its mutants deficient in alginate or all EPS synthesis under controlled matric potentials - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC4287175/#:~:text=Interestingly%2C%20alginate%20synthesis%20regulatory%20genes,in%20the%20alginate%20synthesis%20operon')
41. AnnotationURLCitation(end_index=17118, start_index=16958, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=GMD%20is%20currently%20believed%20to,of%20the%20integration%20host%20factor')
42. AnnotationURLCitation(end_index=17492, start_index=17332, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=GMD%20is%20currently%20believed%20to,of%20the%20integration%20host%20factor')
43. AnnotationURLCitation(end_index=17829, start_index=17676, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=transcription%20of%20the%20algD%20gene,19%20%2C%2025%2C21%20%2C%2027')
44. AnnotationURLCitation(end_index=18219, start_index=18059, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=GMD%20is%20currently%20believed%20to,of%20the%20integration%20host%20factor')
45. AnnotationURLCitation(end_index=18544, start_index=18384, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=GMD%20is%20currently%20believed%20to,of%20the%20integration%20host%20factor')
46. AnnotationURLCitation(end_index=18929, start_index=18802, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=High%20osmolarity%20of%20the%20external,23')
47. AnnotationURLCitation(end_index=19267, start_index=19140, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=High%20osmolarity%20of%20the%20external,23')
48. AnnotationURLCitation(end_index=19539, start_index=19371, title='Colony morphology and transcriptome profiling of Pseudomonas putida KT2440 and its mutants deficient in alginate or all EPS synthesis under controlled matric potentials - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC4287175/#:~:text=no%20genes%20except%20galU%20were,gene%2C%20annotated%20as%20asparagine%20synthetase')
49. AnnotationURLCitation(end_index=19944, start_index=19794, title='Advances in alginate biosynthesis: regulation and production in Azotobacter vinelandii - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC12350332/#:~:text=nitrogen%20and%20its%20high%20respiratory,Insights%20into%20these')
50. AnnotationURLCitation(end_index=20503, start_index=20265, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=Synthetic%20scheme%20of%20alginate%20biosynthesis,triphosphate%2C%20NAD%E2%80%94Nicotinamide%20adenine%20dinucleotide%2C%20LPS%E2%80%94Lipopolysaccharide')
51. AnnotationURLCitation(end_index=21177, start_index=21020, title='Colony morphology and transcriptome profiling of Pseudomonas putida KT2440 and its mutants deficient in alginate or all EPS synthesis under controlled matric potentials - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC4287175/#:~:text=and%20bcs%20genes%20may%20contribute,that%20Bcs%20and%20alginate%2C%20but')
52. AnnotationURLCitation(end_index=21337, start_index=21178, title='Colony morphology and transcriptome profiling of Pseudomonas putida KT2440 and its mutants deficient in alginate or all EPS synthesis under controlled matric potentials - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC4287175/#:~:text=However%2C%20algA%20deletion%20seems%20to,the%20mutants%20was%20asnB%20gene')
53. AnnotationURLCitation(end_index=22402, start_index=22231, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=Alginates%20play%20an%20important%20role,that%20the%20substrate%20oxidation%20reaction')
54. AnnotationURLCitation(end_index=22579, start_index=22403, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=strains%20exhibits%20strong%20negative%20cooperativity,mannose%20dehydrogenase%20inhibition')
55. AnnotationURLCitation(end_index=23029, start_index=22853, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=strains%20exhibits%20strong%20negative%20cooperativity,mannose%20dehydrogenase%20inhibition')
56. AnnotationURLCitation(end_index=23340, start_index=23164, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=strains%20exhibits%20strong%20negative%20cooperativity,mannose%20dehydrogenase%20inhibition')
57. AnnotationURLCitation(end_index=24395, start_index=24251, title='The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10740432/#:~:text=only%20one%20site%20for%20substrate,mannose%20dehydrogenase')
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