bioC

Gene Description

BioC is the S-adenosyl-L-methionine-dependent malonyl-ACP O-methyltransferase that initiates the BioC-BioH route for assembling the pimeloyl-ACP precursor of biotin. Methylation masks the free carboxyl group of malonyl-ACP so the intermediate can pass through fatty-acid-synthase elongation before BioH removes the methyl ester.

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0008168 methyltransferase activity	IEA GO_REF:0000117	MARK AS OVER ANNOTATED	Summary: This generic term is redundant with the substrate-specific BioC activity. Reason: GO:0008168 does not identify the malonyl-ACP substrate or BioC pathway role captured by GO:0102130.
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity	IEA GO_REF:0000002	MARK AS OVER ANNOTATED	Summary: This cofactor-defined parent term is redundant with GO:0102130. Reason: The specific BioC reaction already implies S-adenosyl-L-methionine as methyl donor and is more informative.
GO:0009102 biotin biosynthetic process	IEA GO_REF:0000120	ACCEPT	Summary: BioC initiates pimeloyl-ACP precursor formation for biotin synthesis. Reason: The BioC family assignment, catalytic reaction, and UniProt pathway record consistently place Q88QW9 in biotin biosynthesis.
GO:0010340 carboxyl-O-methyltransferase activity	IEA GO_REF:0000120	MARK AS OVER ANNOTATED	Summary: This chemistry-level parent is accurate but redundant with GO:0102130. Reason: GO:0102130 captures the same O-methylation chemistry with the BioC malonyl-ACP substrate.
GO:0102130 malonyl-CoA methyltransferase activity	IEA GO_REF:0000120	ACCEPT	Summary: This is the specific BioC molecular function. Reason: Despite the current GO label saying malonyl-CoA, the term definition and Rhea grounding describe methylation of malonyl-ACP, matching EC 2.1.1.197 and the Q88QW9 UniProt reaction. Supporting Evidence: file:PSEPK/bioC/bioC-uniprot.txt Full=Malonyl-[acyl-carrier protein] O-methyltransferase file:PSEPK/bioC/bioC-deep-research-openscientist.md Its curated catalytic activity (EC 2.1.1.197, RHEA:17105) is: malonyl-[ACP] + S-adenosyl-L-methionine → malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine.

Core Functions

Methylates the free carboxyl group of malonyl-ACP to initiate pimeloyl-ACP precursor formation in the BioC-BioH biotin-biosynthesis route.

Molecular Function:

malonyl-CoA methyltransferase activity

Directly Involved In:

biotin biosynthetic process

Supporting Evidence:

file:PSEPK/bioC/bioC-uniprot.txt
Full=Malonyl-[acyl-carrier protein] O-methyltransferase
file:PSEPK/bioC/bioC-deep-research-openscientist.md
Its curated catalytic activity (EC **2.1.1.197**, RHEA:17105) is: **malonyl-[ACP] + S-adenosyl-L-methionine → malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine**.

Gene Description

Existing Annotations Review

Core Functions

Methylates the free carboxyl group of malonyl-ACP to initiate pimeloyl-ACP precursor formation in the BioC-BioH biotin-biosynthesis route.

References

Deep Research

OpenScientist

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