FlhA is an integral membrane component of the flagellar type III export apparatus. It coordinates export of flagellar assembly substrates and is required for ordered construction of the rod, hook, and filament.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005886 plasma membrane | IEA GO_REF:0000120 | ACCEPT | Summary: FlhA is a multipass component of the cytoplasmic membrane export gate. Reason: The specific membrane localization is consistent with the conserved FlhA architecture. |
| GO:0009306 protein secretion | IEA GO_REF:0000002 | MODIFY | Summary: FlhA participates in export of flagellar assembly substrates. Reason: GO:0030254 specifically captures secretion through the type III export apparatus in which FlhA acts. Proposed replacements: protein secretion by the type III secretion system Supporting Evidence: file:PSEPK/flhA/flhA-deep-research-openscientist.md FlhA is therefore not a peripheral accessory but one of six integral-membrane proteins that build the transmembrane secretion channel. |
| GO:0016020 membrane | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: FlhA is membrane embedded, but plasma membrane is already annotated more specifically. Reason: Correct but redundant with the more informative plasma-membrane annotation. |
| GO:0044780 bacterial-type flagellum assembly | IEA GO_REF:0000120 | ACCEPT | Summary: Flagellar substrate export through the FlhA-containing gate is required for assembly. Reason: This is the core biological process supported by conserved FlhA function. |
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