flhA

UniProt ID: Q88EV8
Organism: Pseudomonas putida KT2440
Review Status: COMPLETE
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Gene Description

FlhA is an integral membrane component of the flagellar type III export apparatus. It coordinates export of flagellar assembly substrates and is required for ordered construction of the rod, hook, and filament.

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005886 plasma membrane
IEA
GO_REF:0000120
ACCEPT
Summary: FlhA is a multipass component of the cytoplasmic membrane export gate.
Reason: The specific membrane localization is consistent with the conserved FlhA architecture.
GO:0009306 protein secretion
IEA
GO_REF:0000002
MODIFY
Summary: FlhA participates in export of flagellar assembly substrates.
Reason: GO:0030254 specifically captures secretion through the type III export apparatus in which FlhA acts.
Supporting Evidence:
file:PSEPK/flhA/flhA-deep-research-openscientist.md
FlhA is therefore not a peripheral accessory but one of six integral-membrane proteins that build the transmembrane secretion channel.
GO:0016020 membrane
IEA
GO_REF:0000002
KEEP AS NON CORE
Summary: FlhA is membrane embedded, but plasma membrane is already annotated more specifically.
Reason: Correct but redundant with the more informative plasma-membrane annotation.
GO:0044780 bacterial-type flagellum assembly
IEA
GO_REF:0000120
ACCEPT
Summary: Flagellar substrate export through the FlhA-containing gate is required for assembly.
Reason: This is the core biological process supported by conserved FlhA function.

Core Functions

Integral membrane export-gate component coordinating secretion of flagellar assembly substrates.

Cellular Locations:

References

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Deep Research

OpenScientist

(flhA-deep-research-openscientist.md)

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