pgi2

Summary: glucose-6-phosphate isomerase activity is consistent with the curated UniProt name, EC/family evidence, and the gene product role summarized here.

Reason: This is a specific, biologically appropriate annotation for this gene product.

Summary: cytoplasm is consistent with the curated UniProt name, EC/family evidence, and the gene product role summarized here.

Reason: This is a specific, biologically appropriate annotation for this gene product.

Summary: cytosol is consistent with the curated UniProt name, EC/family evidence, and the gene product role summarized here.

Reason: This is a specific, biologically appropriate annotation for this gene product.

Summary: gluconeogenesis is consistent with the curated UniProt name, EC/family evidence, and the gene product role summarized here.

Reason: This is a specific, biologically appropriate annotation for this gene product.

Summary: glycolytic process is a defensible parent term for glucose-6-phosphate isomerase. Refining to GO:0061688 (glycolytic process via Entner-Doudoroff Pathway) is incorrect because the G6P<->F6P isomerization is an EMP/gluconeogenic step and is not part of the Entner-Doudoroff route (F6P is not an ED intermediate); accordingly the ED/gluconeogenesis module places glucose-6-phosphate isomerase under the gluconeogenic bypasses branch rather than the ED branch. GO:0061688 has since been obsoleted (GO release 2026-07-26, replaced_by GO:0006096), which leaves GO:0006096 as the only applicable term.

Reason: Keep the existing glycolytic process annotation as-is; do not refine to the ED-specific child term since pgi is not an ED enzyme.

Summary: monosaccharide binding is biologically plausible for this enzyme but is ancillary to the more specific catalytic function.

Reason: Retain as a supporting/non-core annotation rather than using it as the main functional summary.

Summary: glucose 6-phosphate metabolic process is consistent with the curated UniProt name, EC/family evidence, and the gene product role summarized here.

Reason: This is a specific, biologically appropriate annotation for this gene product.

Summary: carbohydrate derivative binding is a broad parent or generic domain-derived term that adds little beyond the specific catalytic annotation.

Reason: The annotation is not necessarily false, but it is less informative than the specific molecular function already present.

Summary: carbohydrate derivative metabolic process is a broad parent or generic domain-derived term that adds little beyond the specific catalytic annotation.

Reason: The annotation is not necessarily false, but it is less informative than the specific molecular function already present.