Summary: Correct localization for the bacterial inner-membrane succinate dehydrogenase cytochrome b subunit.

Reason: The UniProt SUBCELLULAR LOCATION line rests only on an ARBA rule, so the location is argued from sequence analysis and family membership instead. Phobius predicts three transmembrane helices (FT TRANSMEM 28..49, 69..86, 107..127), and Q88FA5 matches the succinate dehydrogenase cytochrome b556 family (NCBIfam TIGR02970, Pfam PF01127 Sdh_cyt), whose members are the membrane anchor of Complex II. Alpha-helical multi-pass proteins of a Gram-negative bacterium reside in the inner membrane, which corresponds to the GO plasma membrane.

Summary: Correct TCA-cycle annotation because SdhC is part of the SdhABCD succinate dehydrogenase complex.

Reason: The SdhABCD complex catalyzes the succinate-to-fumarate step of the TCA cycle, and SdhC is a membrane anchor/cytochrome b subunit of this required complex. The UniProt PATHWAY line is ARBA-only and is not used; the support is family membership - Q88FA5 matches the succinate dehydrogenase cytochrome b556 models (NCBIfam TIGR02970, CDD cd03499 SQR_TypeC_SdhC) - and the curated PIRSR heme note placing the heme between the two transmembrane subunits of the complex. No KT2440 sdhC mutant data are cached.

Summary: Correct subunit-level role for the cytochrome b membrane domain of succinate dehydrogenase.

Reason: SdhC is the cytochrome b556 membrane subunit of Complex II and contains heme-binding features; it contributes to electron transfer/quinone reduction by the holoenzyme.

Summary: Correct but less precise than the plasma membrane/inner membrane annotation.

Reason: SdhC is a membrane protein, but UniProt specifies the bacterial cell inner membrane and GOA already has the more informative plasma membrane annotation. Use GO:0005886 as the preferred location term.

Proposed replacements: plasma membrane