tal (PP_2168) encodes transaldolase, a type 1 transaldolase family enzyme in the non-oxidative pentose phosphate pathway. It reversibly converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate, helping balance PPP and glycolytic sugar phosphate pools.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0004801 transaldolase activity | IEA GO_REF:0000120 | ACCEPT | Summary: This is the exact catalytic activity for Tal. UniProt describes the non-oxidative PPP transaldolase reaction, and GOA links the term to RHEA:17053, EC 2.2.1.2, and PANTHER:PTN002242200. Reason: GO:0004801 is the core molecular function of tal. Supporting Evidence: file:PSEPK/tal/tal-uniprot.txt Transaldolase involved in the non-oxidative phase in the file:PSEPK/tal/tal-goa.tsv GO:0004801 transaldolase activity file:PSEPK/tal/tal-deep-research-openscientist.md tal / PP_2168 encodes transaldolase (EC 2.2.1.2) |
| GO:0005737 cytoplasm | IEA GO_REF:0000120 | MARK AS OVER ANNOTATED | Summary: Cytoplasm is compatible with the soluble bacterial enzyme, but GOA also contains the more specific cytosol annotation. Reason: Avoid retaining both parent cytoplasm and child cytosol as equally informative locations. |
| GO:0005829 cytosol | IEA GO_REF:0000118 | KEEP AS NON CORE | Summary: Cytosol is the more specific localization for this soluble central-carbon enzyme and is supported by TreeGrafter GOA. Reason: Keep as location context while the catalytic activity remains the core function. Supporting Evidence: file:PSEPK/tal/tal-goa.tsv GO:0005829 cytosol |
| GO:0005975 carbohydrate metabolic process | IEA GO_REF:0000002 | MARK AS OVER ANNOTATED | Summary: The broad carbohydrate metabolic process term is compatible with Tal but redundant with the pentose-phosphate pathway annotation. Reason: GO:0006098 plus the exact transaldolase activity provide more specific biological information. |
| GO:0006098 pentose-phosphate shunt | IEA GO_REF:0000120 | ACCEPT | Summary: Tal catalyzes a core non-oxidative PPP rearrangement, so the pentose-phosphate shunt process term is appropriate. Reason: The process term is directly supported by the enzyme's pathway step. Supporting Evidence: file:PSEPK/tal/tal-uniprot.txt CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D- file:PSEPK/tal/tal-goa.tsv GO:0006098 pentose-phosphate shunt |
| GO:0004801 transaldolase activity | ISS GO_REF:0000024 | ACCEPT | Summary: This manually transferred similarity annotation duplicates the same exact transaldolase activity supported by the UniProt/GOA automated entry. Reason: The duplicated evidence line supports the same correct core molecular function and should be retained. Supporting Evidence: file:PSEPK/tal/tal-goa.tsv GO:0004801 transaldolase activity |
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