XcpU is the GspH-family minor pseudopilin of the type II secretion system. It contributes to the minor-pseudopilin tip or initiation complex that supports assembly and function of the GspG-major pseudopilus.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0015627 type II protein secretion system complex | IEA GO_REF:0000002 | ACCEPT | Summary: XcpU is a GspH-family minor pseudopilin in the T2SS pseudopilus assembly. Reason: The GspH-specific InterPro assignment distinguishes XcpU from unrelated fimbrial proteins. |
| GO:0015628 protein secretion by the type II secretion system | IEA GO_REF:0000002 | ACCEPT | Summary: XcpU supports pseudopilus assembly during type II secretion. Reason: The exact GspH/XcpU family assignment supports the specific process annotation. |
| GO:0005886 plasma membrane | ISS file:PSEPK/xcpU/xcpU-uniprot.txt | NEW | Summary: XcpU is an inner-membrane-anchored minor pseudopilin before and during pseudopilus assembly. Reason: The exact GspH-family assignment and the N-terminal transmembrane segment support bacterial plasma-membrane localization, matching the other membrane-anchored pseudopilins in the complex. Supporting Evidence: file:PSEPK/xcpU/xcpU-uniprot.txt TRANSMEM 12..31 file:PSEPK/xcpU/xcpU-uniprot.txt DR InterPro; IPR049875; TypeII_GspH. |
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