YajC is a small single-pass inner-membrane protein in the conserved YajC family and occurs in SecDF-YajC and bacterial holo-translocon assemblies. Its individual mechanistic contribution to Sec-dependent export remains unresolved, and it has no established independent catalytic or transporter activity.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005886 plasma membrane | IEA GO_REF:0000120 | ACCEPT | Summary: YajC is a single-pass component of the inner-membrane Sec accessory complex. Reason: The exact YajC family assignment and membrane topology support plasma-membrane localization. |
| GO:0031522 cell envelope Sec protein transport complex | ISS PMID:24550475 Membrane protein insertion and proton-motive-force-dependent... | NEW | Summary: YajC is a membrane component of the SecDF-YajC accessory assembly. Reason: The local UniProt record assigns Q88PL6 to the YajC-specific PTHR33909:SF1 subfamily, and the purified bacterial holo-translocon contains the SecDF-YajC subcomplex. Supporting Evidence: PMID:24550475 The bacterial version SecYEG interacts with the highly conserved YidC and SecDF-YajC subcomplex, which facilitates translocation into and across the membrane. file:PSEPK/yajC/yajC-uniprot.txt PANTHER; PTHR33909:SF1; SEC TRANSLOCON ACCESSORY COMPLEX SUBUNIT YAJC; 1. |
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Download this section (compressed HTML)Q: Does KT2440 YajC measurably affect SecDF-SecYEG assembly or export throughput despite the nonessential E. coli phenotype?
Experiment: Quantify SecDF-SecYEG assembly and export throughput in wild type and a clean yajC deletion strain.
Type: Sec-pathway mechanism validation
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